PN Nclex Questions 2024 Related

Review PN Nclex Questions 2024 related questions and content

Narrow therapeutic index medications:

  • A. are drug formulations with limited pharmacokinetic variability.
  • B. have limited value and require no monitoring of blood levels.
  • C. have less than a twofold difference in minimum toxic levels and minimum effective concentration in the blood
  • D. have limited potency and side effects.
Correct Answer: C

Rationale: The therapeutic index is the ratio between the median lethal dose and median effective dose of a drug, indicating the safety margin. Narrow therapeutic index medications have a small difference between minimum toxic levels and minimum effective concentration in the blood, making them high-risk drugs that require close monitoring to avoid toxicity. Choice A is incorrect because pharmacokinetics refer to drug absorption, distribution, metabolism, and elimination, not the therapeutic index. Choice B is incorrect because narrow therapeutic index drugs necessitate monitoring due to their narrow margin of safety. Choice D is incorrect because narrow therapeutic index drugs do not necessarily have limited potency but are characterized by a small window between efficacy and toxicity.