Nokea
NSAIDs increase the risk of CNS adverse effects when taken with which group of antibiotics?
- A. Macrolides
- B. Penicillins
- C. Aminoglycosides
- D. Quinolones
Correct Answer: D
Rationale: Quinolones (e.g., ciprofloxacin) with NSAIDs can increase CNS effects like seizures due to GABA inhibition.
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A nurse is assisting with caring for a client with cancer who is receiving cisplatin. Select the adverse effects that the nurse monitors for that are associated with this medication. (Select one that does not apply.)
- A. Tinnitus
- B. Ototoxicity
- C. Hyperkalemia
- D. Hypomagnesemia
Correct Answer: C
Rationale: Cisplatin is an alkylating medication. Alkylating medications are cell cycle phase-nonspecific medications that affect the synthesis of DNA by causing the cross-linking of DNA to inhibit cell reproduction. Cisplatin may cause ototoxicity, tinnitus, hypokalemia, hypocalcemia, hypomagnesemia, and nephrotoxicity. Amifostine (Ethyol) may be administered before cisplatin to reduce the potential for renal toxicity. Correct answers include: 1 (Tinnitus), 2 (Ototoxicity), 5 (Nephrotoxicity), 6 (Hypomagnesemia).
While caring for a client who is taking furosemide (Lasix), the nurse recognizes dietary teaching has been effective if the patient includes which of the following foods in his daily menus?
- A. Broccoli and kiwi
- B. Oranges and sweet potatoes
- C. Kale and cucumbers
- D. Bananas and melon
Correct Answer: D
Rationale: Furosemide (Lasix) is a loop diuretic that can cause potassium loss; bananas and melon are potassium-rich, aiding in replacing this electrolyte, unlike the other options.
Which of the following drug has the ability to produce hypogliceic effect via closure of ATP-sensitive channels
- A. Glipizide
- B. Metformin
- C. Acarbose
- D. Pramlintide
Correct Answer: A
Rationale: Glipizide, a sulfonylurea, closes ATP-sensitive K+ channels, stimulating insulin release.
What is the correct statement concerning noncompetitive antagonism:
- A. The potency of the drug does not change
- B. the number of receptors able to bind the agonist is affected
- C. by increasing the conc. of the agonist, we cannot overcome the problem
- D. non of the above is wrong
Correct Answer: D
Rationale: All statements are correct: noncompetitive antagonism reduces efficacy (not potency), affects receptor availability, and cannot be overcome by increasing agonist concentration.
A potentially life-threatening adverse response to angiotensin-converting enzyme inhibitors is angioedema. Which of the following statements is true about this adverse response?
- A. Swelling of the tongue or hoarseness are the most common symptoms.
- B. It appears to be related to the decrease in aldosterone production.
- C. Presence of a dry, hacky cough indicates a high risk for this adverse response.
- D. Because it takes time to build up a blood level, it occurs after being on the drug for about 1 week.
Correct Answer: A
Rationale: Angioedema presents with tongue swelling or hoarseness and is not linked to cough or aldosterone.