Nokea
One hypothesis links the cytokine storm associated with SARS and Avian Flu to
- A. Elevated levels of ROS during these infections in the lung
- B. Elevated levels of acute phase proteins
- C. Formation of the inflammasome through activation of NLRP3
- D. Recognition of oxidized forms of a host lipid called PAPC by TLR4
Correct Answer: E
Rationale: I'm sorry, but it seems like there might be a mistake in the question provided as there is no option E listed. Could you please provide the correct answer or clarify the question so that I can assist you further?
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Mutations in which of the following genes are considered a risk factor for Crohn's disease?
- A. TLR-4
- B. NOD2
- C. NADPH oxidase
- D. IL-2
Correct Answer: B
Rationale: The correct answer is B: NOD2. Mutations in the NOD2 gene have been strongly associated with an increased risk of Crohn's disease. NOD2 is involved in the immune response to bacteria in the gut, and mutations in this gene can lead to dysregulation of the immune system, contributing to the development of Crohn's disease.
A: TLR-4 is involved in the recognition of bacterial components but mutations in this gene are not strongly linked to Crohn's disease.
C: NADPH oxidase is important for the production of reactive oxygen species in immune cells but mutations in this gene are not known to be a risk factor for Crohn's disease.
D: IL-2 is a cytokine involved in immune regulation but mutations in this gene are not associated with an increased risk of Crohn's disease.
What is the function of CD14 with respect to LPS recognition?
- A. It is an accessory protein that allows the transport of newly synthesized TLR-4 onto the cell membrane
- B. It is a cytosolic protein that binds LPS that has been internalized via TLR-4/MD-2
- C. It acts as an adaptor in the TLR-4 signaling pathway
- D. It is expressed on the cell membrane and shuttles LPS to the vicinity of TLR-4/MD-2
Correct Answer: D
Rationale: The correct answer is D because CD14 is a glycosylphosphatidylinositol (GPI)-anchored protein expressed on the cell membrane that binds to LPS and facilitates its delivery to the TLR-4/MD-2 complex for recognition. CD14 does not transport TLR-4 (Choice A), bind LPS internally (Choice B), or act as an adaptor in the signaling pathway (Choice C). The key role of CD14 is to shuttle LPS to TLR-4/MD-2, initiating the immune response.
Which of the following is NOT a feature of T cells?
- A. They recognize three-dimensional structures of a pathogen
- B. Their receptors possess specificity
- C. Their receptors have one antigen-binding site
- D. Their antigen receptors are never secreted
Correct Answer: A
Rationale: The correct answer is A because T cells do not recognize three-dimensional structures of a pathogen. T cell receptors interact with processed antigen fragments presented by MHC molecules on antigen-presenting cells. Choice B is correct because T cell receptors possess specificity for antigens. Choice C is incorrect because T cell receptors have multiple antigen-binding sites. Choice D is incorrect as T cell receptors can be secreted as soluble forms.
When assessing a patient for anaphylaxis, be alert for:
- A. Chest pain and indigestion.
- B. Hives and dyspnea.
- C. Hypertension and blurred vision.
- D. Headache and photophobia.
Correct Answer: B
Rationale: Anaphylaxis typically presents with symptoms such as hives (skin reaction) and dyspnea (difficulty breathing), which are indicative of an allergic response affecting the airways and skin. Hypertension and blurred vision are not typical signs of anaphylaxis.
Which of the following is NOT an organ-specific autoimmune disease
- A. Multiple sclerosis
- B. Lupus
- C. Diabetes
- D. Hashimoto's thyroiditis
Correct Answer: B
Rationale: The correct answer is B: Lupus. Lupus is a systemic autoimmune disease that can affect multiple organs and tissues throughout the body, rather than being specific to a single organ. Multiple sclerosis (A) is a neurological autoimmune disease affecting the central nervous system. Diabetes (C) is an autoimmune disease that affects the pancreas. Hashimoto's thyroiditis (D) is an autoimmune disease targeting the thyroid gland. Lupus does not specifically target a single organ, making it the correct choice.