Nokea
Pharmacoeconomics is:
- A. The study of the part of the U.S. economy
- B. The study of the impact of prescription drug costs on the overall economy
- C. The analysis of the costs and consequences of any health-care-related treatment or service
- D. The analysis of the clinical efficacy of the drug
Correct Answer: C
Rationale: Pharmacoeconomics evaluates costs and outcomes of health-care interventions.
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Tamoxifen is prescribed for the client with metastatic breast carcinoma. The nurse understands that the primary action of this medication is to:
- A. Increase DNA and RNA synthesis.
- B. Promote the biosynthesis of nucleic acids.
- C. Increase estrogen concentration and estrogen response.
- D. Compete with estradiol for binding to estrogen in tissues containing high concentrations of receptors.
Correct Answer: D
Rationale: Tamoxifen is an antineoplastic medication that competes with estradiol for binding to estrogen in tissues containing high concentrations of receptors. Tamoxifen is used to treat metastatic breast carcinoma in women and men. Tamoxifen is also effective in delaying the recurrence of cancer following mastectomy. Tamoxifen reduces DNA synthesis and estrogen response.
A nurse is teaching her patient about the use of over-the-counter (OTC) drugs. Which of the following statements best informs the patient about their safe use?
- A. OTC drugs are products that are available without prescription for self-treatment of minor complaints.'
- B. OTC drugs are considered medications and should be reported on a drug history.'
- C. OTC drugs were approved as prescription drugs but later were found to be safe without the need for a prescription.'
- D. OTC drugs need to be taken with caution. They can mask the signs and symptoms of an underlying disease and interfere with prescription drug therapy.'
Correct Answer: D
Rationale: OTC drugs are considered medications and should be reported. OTC drugs are available without a prescription, although some were first approved as prescription drugs. The most important teaching should relate to their safe use and that OTC drugs can mask symptoms of disease and interfere with prescribed drugs.
A client is being treated for tuberculosis. Which medications are used to treat this condition?(Select one that does not apply.)
- A. Streptomycin sulfate
- B. rifabutin
- C. Ethambutol (Myambutol)
- D. Gentamicin (Garamycin)
Correct Answer: D
Rationale: TB treatment uses streptomycin, ethambutol, rifabutin, ethionamide, and pyrazinamide; amoxicillin and gentamicin are not standard. Streptomycin sulfate, ethambutol, rifabutin, ethionamide, and pyrazinamide are used to treat tuberculosis.
The primary action of loop diuretics is to:
- A. Inhibit sodium and chloride reabsorption in the loop of Henle.
- B. Block aldosterone receptors in the distal tubule.
- C. Increase osmolarity of the renal tubular fluid.
- D. Inhibit sodium reabsorption in the proximal tubule.
Correct Answer: A
Rationale: Loop diuretics like furosemide inhibit Na+/Cl- reabsorption in the loop of Henle, increasing urine output.
Which of the following drugs do not cross the placenta
- A. Dilantin
- B. Diazepam
- C. Acinocoumarin
- D. Heparin
Correct Answer: D
Rationale: Heparin does not cross the placenta due to its large size.