Nokea
Pharmacokinetics is:
- A. The study of biological and therapeutic effects of drugs
- B. The study of absorption, distribution, metabolism and excretion of drugs
- C. The study of mechanism of drugs
- D. The study of methods of new drug development
Correct Answer: B
Rationale: Pharmacokinetics focuses on how the body handles a drug, including absorption, distribution, metabolism, and excretion (ADME), distinguishing it from pharmacodynamics, which studies drug effects.
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Glucocorticoids causes:
- A. Inhibition of lipolysis
- B. Disposition of fat in upper and lower extremities
- C. Atrophy of fatty tissue on face and paleness
- D. Catabolism of bone tissue
Correct Answer: D
Rationale: Glucocorticoids promote bone catabolism, leading to osteoporosis by inhibiting osteoblast activity and increasing osteoclast activity.
Protein binding of a drug helps in
- A. Distribution
- B. Prolonging half life
- C. Limiting metabolism
- D. All of the above
Correct Answer: D
Rationale: Protein binding affects distribution (bound drugs stay in plasma), prolongs half-life (less free drug available for clearance), and limits metabolism (bound drug is less accessible to enzymes).
When administering an intradermal injection, the nurse would use a 1-mL syringe with which gauge of needle? Select one that does not apply.
- A. 26 gauge
- B. 27 gauge
- C. 29 gauge
- D. 25 gauge
Correct Answer: C
Rationale: A 1-mL syringe with a 25- to 27-gauge needle that is 1/4 to 5/8 inches long is best suited for intradermal injections.
Which of the following is a thiazolidinediones:
- A. Pioglitazone
- B. Exenatide
- C. Sitagliptine
- D. Chlorpropamide
Correct Answer: A
Rationale: Pioglitazone is a thiazolidinedione that enhances insulin sensitivity via PPAR-gamma.
What describes the action of the body on the drug?
- A. Pharmacodynamics
- B. Pharmacokinetics
- C. Microbiology
- D. Physiology
Correct Answer: B
Rationale: Pharmacokinetics describes how the body affects a drug, including absorption, distribution, metabolism, and excretion, distinct from pharmacodynamics, which is the drug's effect on the body.