Nokea
Prostaglandins play pathophysiological role in the following EXCEPT:
- A. Patency of ductus arteriosus
- B. Regulation of renal tubular salt absorption
- C. Ventricular remodelling after myocardial infarction
- D. Initiation of labour
Correct Answer: C
Rationale: Prostaglandins maintain ductus arteriosus patency, regulate renal salt absorption, and initiate labor, but ventricular remodeling post-myocardial infarction is primarily driven by other factors like cytokines and neurohormones.
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A nurse is teaching a client who has a new prescription for digoxin to treat heart failure. Which of the following instructions should the nurse include in the teaching?
- A. Contact provider if heart rate is less than 60/min.
- B. Check pulse rate for 30 seconds and multiply result by 2.
- C. Increase intake of sodium.
- D. Take with food if nausea occur
Correct Answer: A
Rationale: Bradycardia (<60/min, A) is a sign of digoxin toxicity to report; pulse should be checked for 1 minute.
Nicotine has a variety of effects on nicotinic receptors throughout the body. Which of the following is NOT an effect of nicotine?
- A. Vasodilation and decreased heart rate
- B. Increased secretion of gastric acid and motility of the GI smooth muscle
- C. Release of dopamine at the pleasure center
- D. Stimulation of the locus coeruleus
Correct Answer: A
Rationale: Nicotine causes vasoconstriction and increased heart rate, not vasodilation.
Which statement is false of Domperidone
- A. Chemically related to haloperidol
- B. Pharmacologically related to metoclopramide
- C. Extra pyramidal symptoms are common
- D. It counteracts the emetic action but not the therapeutic effect in parkinsonism
Correct Answer: C
Rationale: Domperidone rarely causes extrapyramidal symptoms as it doesn't cross the blood-brain barrier.
Which of the following is NOT true regarding ligand-gated ion channels?
- A. React quickly to a stimulus or ligand
- B. Can have intracellular binding sites
- C. Can exhibit allosteric binding
- D. Open or close in response to deformations in the cell membrane
Correct Answer: D
Rationale: Ligand-gated channels respond to ligands, not mechanical deformation (which is typical of mechanosensitive channels).
Vitamin B2 (riboflavin) may be prescribed to:
- A. Decrease the incidence of beriberi
- B. Reduce headaches and migraines
- C. Prevent pernicious anemia
- D. Treat hyperlipidemia
Correct Answer: B
Rationale: Riboflavin has been used to reduce migraine frequency, though evidence is limited.