Nokea
Sitagliptin has been approved for:
- A. Monotherapy in once-daily doses
- B. Combination therapy with metformin
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: C
Rationale: Sitagliptin is approved for monotherapy and with metformin , offering flexible type 2 diabetes management.
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The routine monitoring recommended for low molecular weight heparin is:
- A. INR every 2 days until stable, then weekly
- B. aPTT every week while on therapy
- C. Factor Xa levels if the patient is pregnant
- D. White blood cell count every 2 weeks
Correct Answer: C
Rationale: Factor Xa levels may be monitored in pregnancy with LMWH; routine INR or aPTT isn't needed due to predictable pharmacokinetics.
Alpha-beta blockers are especially effective to treat hypertension for which ethnic group?
- A. White
- B. Asian
- C. African American
- D. Native American
Correct Answer: C
Rationale: Alpha-beta blockers are particularly effective in African Americans due to their dual mechanism.
Which medication route provides the most rapid onset of a medication, but also poses the greatest risk of adverse effects?
- A. Intradermal
- B. Subcutaneous (subcut)
- C. Intramuscular (IM)
- D. Intravenous (IV)
Correct Answer: D
Rationale: IV medications are delivered directly into the bloodstream and avoid the first pass effect of the liver. Intradermal, subcut, and IM administration have a slower absorption rate.
Which of the following NSAIDs has greater inhibitory selectivity for COX-1 than COX-2?
- A. Flurbiprofen
- B. Indomethacin
- C. Diclofenac
- D. Celecoxib
Correct Answer: B
Rationale: Indomethacin is more selective for COX-1, whereas celecoxib is COX-2 selective; others have mixed activity.
A patient needs to take 1 g PO of cefadroxil. The drug comes in 500-mg tablets. How many tablets should the patient take?
- A. 0.5 tablet
- B. 1 tablet
- C. 2 tablets
- D. 3 tablets
Correct Answer: C
Rationale: Convert 1 g to mg by multiplying 1 g times 1000 mg. There are 500 mg in each tablet. Dividing the 1000-mg prescribed dosage by the 500-mg available dosage, the answer is 2 tablets.