Questions on Respiratory System Related

Review Questions on Respiratory System related questions and content

TB skin test is called 'Scatch test or Mantoux test' in which Tuberculin Purified Protein Derivative (PPD) is injected subcutaneously. This test is based on

  • A. Delayed Hypersensitivity
  • B. Production of antibodies
  • C. Production of Tubercle toxin
  • D. All these
Correct Answer: A

Rationale: The correct answer is A: Delayed Hypersensitivity. The TB skin test, also known as the Mantoux test, is based on the principle of delayed hypersensitivity reaction. When Tuberculin Purified Protein Derivative (PPD) is injected subcutaneously, in individuals previously exposed to TB, the immune system mounts a delayed hypersensitivity reaction resulting in localized inflammation at the injection site. This reaction is mediated by T cells and is indicative of previous exposure to the TB bacterium.

Incorrect choices:
B: Production of antibodies - The TB skin test does not detect the production of antibodies specific to TB, but rather the cellular immune response.
C: Production of Tubercle toxin - The test is not based on the production of the tubercle toxin, but on the immune response to the tuberculin PPD.
D: All these - While the immune response may involve various components, such as antibodies and cellular responses, the primary basis of the TB skin test is the