Nokea
Tetracycline needs to be given on an empty stomach because it chelates with:
- A. Calcium
- B. Magnesium
- C. Iron
- D. All of the above
Correct Answer: D
Rationale: Tetracycline forms insoluble complexes with divalent and trivalent cations (calcium, magnesium, iron), reducing absorption when taken with food containing these elements.
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The factors contributing to the unequal distribution of drugs are all except:
- A. Heterogenesity of the drug
- B. Binding to plasma proteins
- C. Cellular binding
- D. Concentration in body fat
Correct Answer: A
Rationale: Unequal distribution is due to physiological factors like plasma protein binding, cellular binding, fat concentration, and barriers (e.g., blood-brain barrier), not drug heterogeneity.
After a few weeks on a drug, a patient reports profound thirst and the production of large volumes of dilute urine (polyuria). Which of the following drugs is most likely responsible for the symptoms?
- A. Diazepam
- B. Fluoxetine
- C. Haloperidol
- D. Lithium
Correct Answer: D
Rationale: Lithium causes nephrogenic diabetes insipidus, leading to thirst and polyuria.
Which of the following mechanisms most accurately describes the blocking action of methimazole?
- A. iodine uptake by the thyroid
- B. organification of iodine in the thyroid
- C. peripheral conversion of T4 to T3
- D. peripheral thyroxine (T4) and T3 receptors
Correct Answer: B
Rationale: Methimazole inhibits thyroperoxidase, blocking iodine organification and thyroid hormone synthesis.
Which of the following is a representative of sulfonylurea?
- A. Metformin
- B. Sitagliptine
- C. Acarbose
- D. Chlorpropamide
Correct Answer: D
Rationale: Chlorpropamide is a sulfonylurea that stimulates insulin release from pancreatic beta cells.
Janice has elevated LDL, VLDL, and triglyceride levels. Niaspan, an extended-release form of niacin, is chosen to treat her hyperlipidemia. Due to its metabolism and excretion, which of the following laboratory results should be monitored?
- A. Serum alanine aminotransferase
- B. Serum amylase
- C. Serum creatinine
- D. Phenylketonuria
Correct Answer: A
Rationale: Niacin can cause hepatotoxicity, requiring ALT monitoring.