Nokea
The antidote for paracetamol poisoning is:
- A. Acetylsalicylic acid
- B. Acetylcysteine
- C. Prostacyclin
- D. Omeprazole
Correct Answer: B
Rationale: Acetylcysteine replenishes glutathione, detoxifying paracetamol's toxic metabolite.
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In the blood glucocorticoids cause:
- A. Increase amount of eosinophles
- B. Lymphocytosis
- C. Increase amount of neutrophils
- D. Increase amount of basophiles
Correct Answer: C
Rationale: Glucocorticoids increase neutrophils while decreasing eosinophils and lymphocytes in the blood.
The nurse uses what term to describe the drug level required to have a therapeutic effect?
- A. Critical concentration
- B. Dynamic equilibrium
- C. Selective toxicity
- D. Active transport
Correct Answer: A
Rationale: A critical concentration of a drug must be present before a reaction occurs within the cells to bring about the desired therapeutic effect. A dynamic equilibrium is obtained from absorption of a drug from the site of drug entry, distribution to the active site, metabolism in the liver, and excretion from the body to have a critical concentration. Selective toxicity is the ability of a drug to attach only to those systems found in foreign cells. Active transport is the process that uses energy to actively move a molecule across a cell membrane and is often involved in drug excretion in the kidney.
The following class of drugs may be used to treat Parkinsonian syndrome arising from the use of phenothiazines:
- A. Nicotinic receptor antagonists
- B. Muscarinic receptor antagonists
- C. Adrenoceptor antagonists
- D. Anticholinesterases
Correct Answer: B
Rationale: Antimuscarinics (e.g., benztropine) relieve parkinsonism from phenothiazines.
The client with acute myelocytic leukemia is being treated with busulfan (Myleran). Which laboratory value would the nurse specifically monitor during treatment with this medication?
- A. Clotting time
- B. Uric acid level
- C. Potassium level
- D. Blood glucose level
Correct Answer: B
Rationale: Busulfan (Myleran) can cause an increase in the uric acid level. Hyperuricemia can produce uric acid nephropathy, renal stones, and acute renal failure. Options 1, 3, and 4 are not specifically related to this medication.
Phase IV clinical trials in the United States are also known as:
- A. Human bioavailability trials
- B. Post marketing research
- C. Human safety and efficacy studies
- D. The last stage of animal trials before the human trials begin
Correct Answer: B
Rationale: Phase IV is post-marketing research , monitoring drugs after approval, unlike earlier phases or animal studies.