Disorders of the Genitourinary System Related

Review Disorders of the Genitourinary System related questions and content

The drug of choice for treatment and secondary prophylaxis against cryptococcal meningitis among AIDS patients is:

  • A. Amphotericin B
  • B. Flucytosine
  • C. Fluconazole
  • D. Ketoconazole
Correct Answer: C

Rationale: Step-by-step rationale:
1. Fluconazole is preferred due to its efficacy, safety, and tolerability in Cryptococcal meningitis.
2. It has better CNS penetration compared to other azoles.
3. It is less toxic than Amphotericin B and Flucytosine.
4. Ketoconazole is less effective and not recommended for this indication.

Summary:
- A: Amphotericin B is reserved for severe cases due to its toxicity.
- B: Flucytosine is used in combination therapy but not as the primary drug of choice.
- D: Ketoconazole is less effective and not preferred for Cryptococcal meningitis in AIDS patients.