Nokea
The following antibiotics interfere with bacterial translation:
- A. Penicillin
- B. Ceftriaxone
- C. Azithromycin
- D. Ciprofloxacin
Correct Answer: C
Rationale: Azithromycin, a macrolide antibiotic, inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with translation.
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Which of the following is false regarding right ventricle?
- A. It has fine and regular trabeculations
- B. Septal attachment of AV valve is more apical
- C. Moderator band is present
- D. Trabecular septomarginalis is present
Correct Answer: A
Rationale: The right ventricle typically has coarse trabeculations, not fine and regular ones.
Azathioprine:
- A. Is a prodrug
- B. Is teratogenic
- C. Should be avoided in liver disease
- D. Dose should be increased when given with allopurinol
Correct Answer: A
Rationale: Azathioprine is a prodrug. It is not highly teratogenic, can be used in liver disease with caution, and its dose should be reduced with allopurinol.
In homo cystinuria:
- A. Homocysteine accumulates just proximal to the enzyme defect
- B. Osteoporosis is a recognised feature
- C. Oral contraceptive pills with oestrogens are contraindicated
- D. Dislocation of lens is a feature
Correct Answer: D
Rationale: Dislocation of the lens is a well-documented feature of homocystinuria due to the accumulation of homocysteine, which affects connective tissue.
In D-transposition of the great vessels, accounts for =5% of all congenital heart disease. In this anomaly, the following are true EXCEPT
- A. the pulmonary artery is anterior and to the left of the aorta
- B. pulmonary veins return to the left atrium
- C. connections between the atria and ventricles are normal
- D. aorta is posterior and to the right of the pulmonary artery
Correct Answer: A
Rationale: The pulmonary artery is anterior and to the left of the aorta in normal anatomy.
Chief organ systems affected in acute graft-versus-host reaction are:
- A. Skin
- B. Renal system
- C. Gut
- D. CNS
Correct Answer: A
Rationale: The skin is one of the primary organ systems affected in acute graft-versus-host disease. The renal system, gut, and CNS can also be affected, but the skin is the most commonly involved.