Nokea
The hypoglycemic mechanism of action of pioglitazone and rosiglitazon is:
- A. They are peroxisome proliferator activating receptor gamma (PPAR-Y) ligands and enhance absorption of glucose and fatty acid
- B. Enhance closure of ATP sensitive K+ channels and entrance of calcium in intracellular efflux via Ca2+ channels
- C. Decrease gluconeogenesis in the liver
- D. Increase tyrosine kinase activity
Correct Answer: A
Rationale: Pioglitazone and rosiglitazone activate PPAR-gamma, improving insulin sensitivity and glucose uptake in tissues.
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Adverse event of alfa glucosidase inhibitors is:
- A. Disorder of intestine function
- B. Weight gain
- C. Acidosis
- D. Allergy reactions
Correct Answer: A
Rationale: Alpha-glucosidase inhibitors like acarbose cause intestinal issues (e.g., flatulence) due to undigested carbohydrates.
Digoxin may cause a type A adverse drug reaction due to:
- A. Idiosyncratic effects
- B. Its narrow therapeutic index
- C. Being a teratogen
- D. Being a carcinogen
Correct Answer: B
Rationale: Digoxin's narrow therapeutic index leads to Type A (dose-related) ADRs like toxicity, not idiosyncratic or teratogenic/carcinogenic effects .
Which statement best describes drug efficacy/toxicity in pediatric clients?
- A. Drug requirements for infants have been extensively studied.
- B. Drug dosage is altered by age and weight in children.
- C. Children always need smaller doses of medication than adults.
- D. Infants and children are always at greater risk for drug toxicity with any medication.
Correct Answer: B
Rationale: Pediatric dosing adjusts for age and weight to ensure efficacy and minimize toxicity, reflecting developmental differences.
Prescribing less-expensive generic drugs or drugs off the 4 retail pharmacy lists:
- A. Increases the complexity of the pharmacoeconomics of prescribing for the individual patient
- B. Increases compliance by reducing the financial burden of drug costs to the patient
- C. Is not sound prescribing practice due to the inferiority of the generic products
- D. Will increase the overall cost of drugs to the system due to the ease of overprescribing less-expensive drugs
Correct Answer: B
Rationale: Generic drugs improve adherence by lowering patient costs.
You prescribe bromocriptine for a woman with primary amenorrhea. Normal menstruation returns about a month after starting therapy. Which of the following statements best describes the mechanism by which bromocriptine caused its desired effects?
- A. Blocked estrogen receptors, enhanced gonadotropin release
- B. Increased FSH synthesis
- C. Inhibited prolactin release
- D. Stimulated ovarian estrogen and progestin synthesis
Correct Answer: C
Rationale: Bromocriptine, a dopamine agonist, inhibits prolactin, restoring ovulation in hyperprolactinemia.