Nokea
The major mechanism of gemfibrozil is:
- A. Increased expression of high-affinity LDL receptors
- B. Inhibition of secretion of VLDL by the liver
- C. Reduction of secretion of HDL by the liver
- D. Increased lipid hydrolysis by lipoprotein lipase
Correct Answer: D
Rationale: Gemfibrozil activates lipoprotein lipase, enhancing triglyceride hydrolysis.
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Phase IV clinical trials in the United States are also known as:
- A. Human bioavailability trials
- B. Post marketing research
- C. Human safety and efficacy studies
- D. The last stage of animal trials before the human trials begin
Correct Answer: B
Rationale: Phase IV is post-marketing research , monitoring drugs after approval, unlike earlier phases or animal studies.
When assessing a patient before starting a drug regimen, why would the nurse consider it important to assess baseline kidney function?
- A. To anticipate adverse effects of drugs
- B. To determine patient's baseline electrolyte levels
- C. To determine patient's ability to excrete the drug
- D. To determine patient's ability to metabolize the drug
Correct Answer: C
Rationale: Kidney function determines drug excretion, critical for dosing and avoiding toxicity.
Which action will the nurse take when it is determined that the narcotic count is incorrect while obtaining a medication from the narcotic area?
- A. Determine the cause of the discrepancy at the end of the shift.
- B. Notify the health care provider stat.
- C. Call the nurse from the previous shift to determine if there was a discrepancy earlier.
- D. Report the discrepancy to the charge nurse immediately.
Correct Answer: D
Rationale: Reporting the discrepancy to the charge nurse immediately enables the supervisory staff to narrow the time frame during which a medication was taken and not documented. The discrepancy needs to be addressed immediately, and therefore determining the cause of the discrepancy at the end of the shift is not the most appropriate action for the nurse to take. It is not appropriate to contact the health care provider for an incorrect narcotic count. The count would have been verified at shift change; calling the nurse from the previous shift is not an appropriate action for the nurse to take.
Plasma concentration of drug at time 0 is 96(g/ml). If t½ is 2 hours concentration in plasma at 10 hours will be
- A. 48
- B. 24
- C. 12
- D. 3
Correct Answer: D
Rationale: In first-order kinetics, the concentration halves every half-life (t½ = 2 hours). At 10 hours (5 half-lives), 96 → 48 → 24 → 12 → 6 → 3 µg/ml.
A nurse is assessing a pregnant client and learns that the client is addicted to cocaine. The nurse informs the client about the risks of cocaine addiction for her fetus. Which of the following would the nurse include?
- A. The child may be born with diabetes.
- B. The child may be born with hypertension.
- C. The child may be born with an addiction to drugs.
- D. The child may be born with CNS defects.
Correct Answer: C
Rationale: The nurse informs the client that children born to mothers using addictive drugs are often born with an addiction to the drug. Children born to mothers who are addicted to cocaine are not known to be born with diabetes, CNS defects, or hypertension.