Nokea
The major mechanism of gemfibrozil is:
- A. Increased expression of high-affinity LDL receptors
- B. Inhibition of secretion of VLDL by the liver
- C. Reduction of secretion of HDL by the liver
- D. Increased lipid hydrolysis by lipoprotein lipase
Correct Answer: D
Rationale: Gemfibrozil activates lipoprotein lipase, enhancing triglyceride hydrolysis.
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B-Blockers are contra indicated in
- A. Hypertension
- B. Congestive cardiac failure
- C. Anxiety states
- D. Hyperthyroidis m
Correct Answer: B
Rationale: Beta-blockers worsen congestive heart failure.
A nurse is assessing a pregnant client and learns that the client is addicted to cocaine. The nurse informs the client about the risks of cocaine addiction for her fetus. Which of the following would the nurse include?
- A. The child may be born with diabetes.
- B. The child may be born with hypertension.
- C. The child may be born with an addiction to drugs.
- D. The child may be born with CNS defects.
Correct Answer: C
Rationale: The nurse informs the client that children born to mothers using addictive drugs are often born with an addiction to the drug. Children born to mothers who are addicted to cocaine are not known to be born with diabetes, CNS defects, or hypertension.
A young adult is receiving a maintenance dose of aminophylline, 3 mg/kg PO q6h. The patient weighs 50 kg. How much should the patient receive in a 24-hour period?
- A. 200 mg
- B. 400 mg
- C. 600 mg
- D. 800 mg
Correct Answer: C
Rationale: Use the formula, amount of drug prescribed weight of the patient in kg 4 (q6h in a 24-hour period = 4). 3 50 = 150 mg to be given every 6 hours. To determine how much the patient will receive in a 24-hour period, divide 6 into 24 to equal 4 doses. 4 150 = 600 mg.
When administering parenteral drugs, which of the following routes would the nurse use? (Select one that does not apply.)
- A. Subcutaneous
- B. Intramuscular
- C. Intradural
- D. Intravenous
Correct Answer: C
Rationale: A nurse can administer parenteral drugs via subcutaneous, intramuscular, intravenous, intradermal, and, in some instances, intra-arterial routes by means of a catheter placed by a physician in an artery. The primary health care provider can administer a drug via the intradural route.
The drug, which interferes with metabolism of theophylline
- A. Gentamicin
- B. Penicillin
- C. Erythromycin
- D. Sulfonamide
Correct Answer: C
Rationale: Erythromycin inhibits cytochrome P-450, reducing theophylline metabolism.