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The nurse is caring for a client receiving tamoxifen (Nolvadex) for breast cancer. Which side effect should the nurse monitor for?
- A. Hot flashes
- B. Hair loss
- C. Nausea
- D. Diarrhea
Correct Answer: A
Rationale: Tamoxifen, an estrogen receptor modulator, treats breast cancer but blocks estrogen in some tissues, causing hot flashes , a common menopausal-like effect. Monitoring this ensures client comfort and adherence, as it's frequent and distressing. Hair loss is more chemotherapy-related, not tamoxifen. Nausea and diarrhea occur less often and are less specific. Hot flashes align with tamoxifen's anti-estrogenic action, a key consideration in breast cancer management where long-term use is common. This focus aids in symptom management, distinguishing it from cytotoxic effects, making A the priority side effect to monitor.
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What is the antidote for Heparin?
- A. Atropine
- B. Protamine sulfate
- C. Calcium carbonate
- D. Ferrous sulfate
Correct Answer: B
Rationale: Protamine sulfate is the specific antidote used to reverse the effects of Heparin by binding to heparin and neutralizing its anticoagulant properties. It is crucial to administer Protamine sulfate promptly in cases of Heparin overdose or when immediate reversal of Heparin's effects is required to prevent bleeding complications. Atropine is not the antidote for Heparin; it is commonly used for treating bradycardia. Calcium carbonate is used to treat conditions like acid indigestion, heartburn, or calcium deficiency. Ferrous sulfate is a form of iron supplement used to treat or prevent iron deficiency anemia. None of these alternatives are antidotes for Heparin.
When educating a patient about Regular Insulin, you should include which instruction: ATI PHARMACOLOGY LATEST UPDATE 2022/2023 PROCTORED EXAM -STUDY GUIDE QUESTIONS & ANS 100% CORRECTLY VERIFIED GRADED A+ ATI PHARMACOLOGY LATEST UPDATE 2022/2023 PROCTORED EXAM -STUDY GUIDE QUESTIONS & ANS 100% CORRECTLY VERIFIED GRADED A+
- A. Shake the vial vigorously
- B. Expect the solution to appear cloudy
- C. Store unopened vials at room
- D. Inject the insulin subcutaneously
Correct Answer: D
Rationale: It is important to educate a patient that Regular Insulin should be injected subcutaneously to ensure proper absorption of the medication. Injecting the insulin into the subcutaneous tissue allows for a slower and more consistent absorption of the medication, which helps in controlling blood glucose levels effectively. Administering insulin subcutaneously also minimizes the risk of complications associated with other injection sites or techniques.
Drugs can cause adverse events in a patient. Bone marrow toxicity is one of the most frequent types of drug-induced toxicity. The most serious form of bone marrow toxicity is:
- A. Aplastic anemia.
- B. Thrombocytosis.
- C. Leukocytosis.
- D. Granulocytosis.
Correct Answer: A
Rationale: Aplastic anemia is the most severe form of bone marrow toxicity, characterized by pancytopenia and bone marrow failure. It can be life-threatening and requires immediate intervention. Thrombocytosis, leukocytosis, and granulocytosis are not typically associated with drug-induced bone marrow toxicity.
When administering medications to a 4-month-old infant, which of the following pharmacokinetic principles should be considered? (Select all that apply.)
- A. Infants have a more rapid gastric emptying time.
- B. Infants have immature liver function.
- C. Infants' blood-brain barrier is poorly developed.
- D. Infants have an increased ability to absorb topical medications.
Correct Answer: B
Rationale: When administering medications to a 4-month-old infant, the pharmacokinetic principle to consider is that infants have immature liver function until 1 year of age. This requires medications metabolized by the liver to be administered in smaller dosages. While infants do have a more rapid gastric emptying time, immature liver function is a more critical pharmacokinetic consideration in this context. Additionally, although infants have a poorly developed blood-brain barrier, this relates more to pharmacodynamic effects rather than pharmacokinetic principles. The statement about infants having an increased ability to absorb topical medications is not directly related to pharmacokinetic principles, making choice B the correct answer.
A client with breast cancer is being taught about Tamoxifen. Which of the following adverse effects of tamoxifen should the client be informed about?
- A. Irregular heart rhythm
- B. Abnormal uterine bleeding
- C. Yellowing of the sclera or dark-colored urine
- D. Difficulty swallowing
Correct Answer: B
Rationale: Abnormal uterine bleeding is a known adverse effect of tamoxifen. It is important to educate the client about this side effect as those taking tamoxifen are at an increased risk for endometrial cancer. Any abnormal uterine bleeding should be promptly reported and evaluated by healthcare providers to ensure timely management and monitoring. The other options, such as irregular heart rhythm, yellowing of the sclera or dark-colored urine, and difficulty swallowing, are not typically associated with tamoxifen use and are not commonly reported adverse effects. Therefore, they are not the priority adverse effects to inform the client about.