Microbiology An Introduction Test Bank

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The patient 25 y.o. was admitted on the 1st day of the disease with complaints of double vision in the eyes, heavy breathing. The day before the patient ate homemade mushrooms. On objective examination: paleness, widened pupils, disorder of swallowing, bradycardia, constipation are marked. What is the diagnosis?

  • A. Botulism
  • B. Yersiniosis
  • C. Leptospirosis
  • D. Salmonellosis, gastrointestinal form
Correct Answer: A

Rationale: The correct answer is A: Botulism. Botulism is a rare but serious illness caused by a toxin produced by the bacterium Clostridium botulinum. In this case, the patient's symptoms align with botulism due to the ingestion of homemade mushrooms. The symptoms of double vision, heavy breathing, paleness, widened pupils, swallowing difficulties, bradycardia, and constipation are all classic signs of botulism poisoning. The toxin affects the nervous system and can lead to paralysis. The other choices (B: Yersiniosis, C: Leptospirosis, D: Salmonellosis) do not match the patient's symptoms and history of consuming mushrooms, making them incorrect.

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The most important virulence factor of Bordetella pertussis is:

  • A. the flagellum
  • B. pertussis toxin
  • C. P fimbriae
  • D. mannose-resistant adhesins
Correct Answer: B

Rationale: The correct answer is B: pertussis toxin. This toxin is the most important virulence factor of Bordetella pertussis because it plays a key role in causing the characteristic symptoms of whooping cough. Pertussis toxin interferes with the host's immune response, leading to inflammation and tissue damage in the respiratory tract. The other choices (A: the flagellum, C: P fimbriae, D: mannose-resistant adhesins) are important for bacterial attachment and colonization, but they do not directly contribute to the severity of the disease like pertussis toxin does.

Microscopic examination of pus sample taken from mandibular fistula canal and stained by Gram's method has revealed druses with gram-positive coloring in the center and cone-shaped structures with gram-negative coloring. Such morphology is characteristic of the agent of:

  • A. Fusobacteriosis
  • B. Actinomycosis
  • C. Staphylococcal osteomyelitis
  • D. Anaerobic infection
Correct Answer: B

Rationale: The correct answer is B: Actinomycosis. Actinomyces is a gram-positive bacterium that forms sulfur granules (druses) with gram-positive coloring in the center and filamentous structures resembling cones with gram-negative coloring. This morphology is characteristic of Actinomyces species. Fusobacteriosis (choice A) typically presents with gram-negative rods. Staphylococcal osteomyelitis (choice C) is caused by gram-positive staphylococci, not Actinomyces. Anaerobic infections (choice D) can be caused by various bacteria, but the specific morphology described in the question matches Actinomyces, making choice B the correct answer.

Which of the following bacteria is known for producing a neurotoxin that causes botulism?

  • A. Clostridium botulinum
  • B. Clostridium perfringens
  • C. Streptococcus pneumoniae
  • D. Neisseria gonorrhoeae
Correct Answer: A

Rationale: The correct answer is A: Clostridium botulinum. This bacterium produces the neurotoxin responsible for botulism. Clostridium perfringens is associated with gas gangrene, not botulism. Streptococcus pneumoniae causes pneumonia, and Neisseria gonorrhoeae causes gonorrhea, not botulism. Therefore, A is the correct choice.

UN volunteers have arrived in Nigeria to assist the locals in aftermath of earthquakes. What drug should they prescribe for individual chemoprophylaxis of malaria?

  • A. Chingamin
  • B. Pyrantel
  • C. Pyrimethamine (Chloridinum)
  • D. Primaquine
Correct Answer: D

Rationale: The correct answer is D: Primaquine. Primaquine is used for individual chemoprophylaxis of malaria caused by Plasmodium vivax and Plasmodium ovale. It is effective in preventing the relapse of these malaria species by eliminating the liver forms of the parasites. Chingamin (A) is not a commonly used drug for malaria prophylaxis. Pyrantel (B) is an anthelmintic drug used for treating parasitic worm infections, not malaria. Pyrimethamine (Chloridinum) (C) is primarily used in combination with sulfadoxine for treating uncomplicated malaria, not for chemoprophylaxis.

A child presented with foul-smelling diarrhea. Stool microscopy revealed trophozoites with two nuclei and flagella. What is the causative agent?

  • A. Giardia lamblia
  • B. Entamoeba histolytica
  • C. Trichomonas vaginalis
  • D. Balantidium coli
Correct Answer: A

Rationale: The correct answer is A: Giardia lamblia. Giardia lamblia is a protozoan parasite that causes foul-smelling diarrhea. The trophozoites of Giardia lamblia have two nuclei and flagella, which are characteristic features seen on stool microscopy. The presence of these specific features helps differentiate Giardia lamblia from the other options. Entamoeba histolytica (B) typically presents with one nucleus and lacks flagella. Trichomonas vaginalis (C) is a sexually transmitted parasite with a different morphology. Balantidium coli (D) is a ciliated parasite, not flagellated like Giardia lamblia.

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