Nokea
Therapeutic index of a drug is an indicator of
- A. Potency
- B. Safety
- C. Toxicity
- D. Efficacy
Correct Answer: C
Rationale: Therapeutic index (TD50/ED50) measures the margin between therapeutic and toxic doses.
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Oral iron supplements are prescribed for a 6 year-old child with iron deficiency anemia. The nurse instructs the mother to administer the iron with which best food item?
- A. Milk
- B. Water
- C. Apple juice
- D. Orange juice
Correct Answer: D
Rationale: Vitamin C increases the absorption of iron by the body. The mother should be instructed to administer the medication with a citrus fruit or a juice that is high in vitamin C. Milk may affect absorption of the iron. Water will not assist in absorption. Orange juice contains a greater amount of vitamin C than apple juice.
Which cephalosporin generation is effective against methicillin-resistant Staphylococcus aureus (MRSA)?
- A. First generation
- B. Second generation
- C. Third generation
- D. Fifth generation
Correct Answer: D
Rationale: Fifth-generation cephalosporins, like ceftaroline, are effective against MRSA, unlike earlier generations.
Which of the following is the indication for glucocorticoid prescribing?
- A. Cataract
- B. Prevention of respiratory distress
- C. Hypofunction of thyroid gland
- D. Hypocalcemia
Correct Answer: B
Rationale: Glucocorticoids are indicated to prevent respiratory distress, such as in preterm infants for lung maturation.
Which lab test(s) would be used to assess liver and/or renal function before administering medications? (Select one that does not apply.)
- A. CBC
- B. LDH
- C. ALT
- D. Crs
Correct Answer: A
Rationale: Liver function tests include LDH (lactic dehydrogenase) and ALT (alanine aminotransferase). Renal function tests include Crs (serum creatinine) and BUN (blood urea nitrogen). Although a CBC (complete blood count) and an aPTT are useful in assessing the patient before administration of medication, they are not renal or hepatic function tests.
Glucocorticoid effects of carbohydrate metabolism is facilitated with:
- A. Gluconeogenesis
- B. Hypoglicemia
- C. Enhance of glucose utilization with peripherial tissues
- D. Decrease of glycogen reserve in the liver
Correct Answer: A
Rationale: Glucocorticoids promote gluconeogenesis, increasing blood glucose levels by converting non-carbohydrate sources into glucose.