This graph illustrates the dose-response relationship for the effect of the beta agonist isoproterenol on an isolated perfused heart, both alone and in the presence of different fixed concentrations of Drug X. Based upon the data shown, Drug X is most likely a(n):
- A. beta agonist
- B. competitive antagonist
- C. irreversible antagonist
- D. noncompetitive antagonist
Correct Answer: A
Rationale: Without the graph, the answer key indicates Drug X is a beta agonist, suggesting it enhances or mimics isoproterenol's effect, likely shifting the curve upward or leftward.
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Which of the following anti inflammatory drugs is ineffective in gout?
- A. Piroxicam
- B. Tolmetin
- C. Aspirin
- D. Celecoxib
Correct Answer: C
Rationale: Aspirin increases uric acid levels, worsening gout.
In response to the patient's question about how to know whether drugs are safe, the nurse explains that all medications undergo rigorous scientific testing controlled by what organization?
- A. Food and Drug Administration (FDA)
- B. Drug Enforcement Agency (DEA)
- C. Centers for Disease Control and Prevention (CDC)
- D. Joint Commission on Accreditation of Healthcare Organizations (JCAHO)
Correct Answer: A
Rationale: The FDA is responsible for controlling and regulating the development and sale of drugs in the United States, allowing new drugs to enter the market only after being subjected to rigorous scientific testing. The DEA regulates and controls the use of controlled substances. The CDC monitors and responds to infectious diseases. The JCAHO is an accrediting body that inspects acute care facilities to ensure minimum standards are met.
Which topical antifungal medication is used to treat vaginal candidiasis?
- A. Haloprogin (Halotex)
- B. Miconazole (Monistat)
- C. Oxiconazole (Oxistat)
- D. Terbinafine HCl (Lamisil)
Correct Answer: B
Rationale: Miconazole is a standard topical treatment for vaginal candidiasis; others target skin infections. Topical miconazole is used to treat vaginal candidiasis.
Six-year-old Lucy has recently been started on ethosuximide (Zarontin) for seizures. She should be monitored for:
- A. Increased seizure activity, as this drug may auto-induce seizures
- B. Altered renal function, including renal failure
- C. Blood dyscrasias, which are uncommon but possible
- D. Central nervous system excitement, leading to insomnia
Correct Answer: C
Rationale: Ethosuximide can rarely cause blood dyscrasias, requiring monitoring.
Alpha-beta blockers are especially effective to treat hypertension for which ethnic group?
- A. White
- B. Asian
- C. African American
- D. Native American
Correct Answer: C
Rationale: Alpha-beta blockers are particularly effective in African Americans due to their dual mechanism.
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