Nokea
Which of the following NSAIDs has greater inhibitory selectivity for COX-1 than COX-2?
- A. Flurbiprofen
- B. Indomethacin
- C. Diclofenac
- D. Celecoxib
Correct Answer: B
Rationale: Indomethacin is more selective for COX-1, whereas celecoxib is COX-2 selective; others have mixed activity.
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Which of the following medications has not hypoglycemic effect:
- A. Insulin
- B. Glucagon
- C. Metformin
- D. Glibenclamid
Correct Answer: B
Rationale: Glucagon raises blood glucose levels, unlike the others which lower it.
A nurse is monitoring a client who takes aspirin 81 mg PO daily. The nurse should identify which of the following manifestations as adverse effects of daily aspirin therapy? (Select one that does not apply.)
- A. Hypertension
- B. Coffee-ground emesis
- C. Tinnitus
- D. Nausea
Correct Answer: A
Rationale: Aspirin can cause GI bleeding , tinnitus , and nausea ; 'possessias' is likely a typo.
A patient is receiving digoxin as treatment for heart failure. Which of the following would be most important for the nurse to monitor to reduce the risk for toxicity?
- A. Seizure activity
- B. Drug blood level
- C. Urinary output
- D. Blood pressure
Correct Answer: B
Rationale: The nurse should monitor the patient's blood level of the drug to ensure that the level remains within the therapeutic range. Monitoring seizure activity, urination frequency, and blood pressure will not prevent toxicity. Seizure activity is unrelated to digoxin or heart failure.
Which statement best describes drug efficacy/toxicity in pediatric patients?
- A. Drug requirements for infants have been extensively studied.
- B. Drug dosage is altered by age and weight in children.
- C. Children always need smaller doses of medication than adults.
- D. Infants and children are not at risk for drug toxicity if the dosage is correct
Correct Answer: B
Rationale: Pediatric dosing adjusts for age and weight due to varying metabolism and body composition.
If an agonist can produce maximal effects and has high efficacy it's called:
- A. Partial agonist
- B. Antagonist
- C. Agonist-antagonist
- D. Full agonist
Correct Answer: D
Rationale: A full agonist achieves maximal receptor activation and effect.