Nokea
Which of the following is synthetic mineralocorticoids:
- A. Testosterone
- B. Estradiol
- C. Fludrocortisone
- D. Hydrocortisone
Correct Answer: C
Rationale: Fludrocortisone is a synthetic mineralocorticoid used to mimic aldosterone's effects on sodium retention.
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A nurse is reviewing a new prescription for oxcarbazepine with a female client who has partial seizures. Which of the following instructions should the nurse include?
- A. Use caution if given a prescription for a diuretic medication.
- B. Consider using oral contraceptives.
- C. Chew gum to increase saliva production.
- D. Avoid driving until you see how the medication affects you.
Correct Answer: D
Rationale: Oxcarbazepine reduces contraceptive efficacy , requires driving caution , and rash monitoring .
A genetic variation in how the metabolite of the cancer drug irinotecan SN-38 is inactivated by the body may lead to:
- A. Decreased effectiveness of irinotecan in the treatment of cancer
- B. Increased adverse drug reactions, such as neutropenia
- C. Delayed metabolism of the prodrug irinotecan into the active metabolite SN-38
- D. Increased concerns for irinotecan being carcinogenic
Correct Answer: B
Rationale: UGT1A1 mutations slow SN-38 inactivation, raising neutropenia risk , not affecting efficacy or activation .
In response to the patient's question about how to know whether drugs are safe, the nurse explains that all medications undergo rigorous scientific testing controlled by what organization?
- A. Food and Drug Administration (FDA)
- B. Drug Enforcement Agency (DEA)
- C. Centers for Disease Control and Prevention (CDC)
- D. Joint Commission on Accreditation of Healthcare Organizations (JCAHO)
Correct Answer: A
Rationale: The FDA is responsible for controlling and regulating the development and sale of drugs in the United States, allowing new drugs to enter the market only after being subjected to rigorous scientific testing. The DEA regulates and controls the use of controlled substances. The CDC monitors and responds to infectious diseases. The JCAHO is an accrediting body that inspects acute care facilities to ensure minimum standards are met.
All of following are examples of prodrugs except
- A. Levodopa
- B. Enlapril
- C. Omeprazole
- D. Indomethacin
Correct Answer: D
Rationale: Prodrugs (e.g., levodopa, enalapril, omeprazole) are inactive until metabolized. Indomethacin is active as administered.
A nurse reviewing a client's health record notes a new prescription for Lisinopril 10 mg PO once every day. The nurse should identify this as which of the following types of prescription?
- A. Single
- B. Stat
- C. Routine
- D. Standing
Correct Answer: C
Rationale: A daily dose (once every day) indicates a routine prescription for ongoing treatment.