Nokea
Up to 21% of Asians are ultra-rapid 2D6 metabolizers, requiring:
- A. A need to monitor drugs metabolized by 2D6 for toxicity
- B. Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors
- C. Decreased conversion of codeine to morphine by CYP 2D6
- D. The need for lowered dosages of drugs, such as beta blockers
Correct Answer: B
Rationale: Ultra-rapid 2D6 metabolizers (e.g., in Asians) need higher SSRI doses due to fast metabolism, unlike toxicity , codeine issues , or lower doses .
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Not an antidepressant
- A. Amitryptilline
- B. Fluoxetin
- C. Trazodone
- D. Pimozide
Correct Answer: D
Rationale: Pimozide is an antipsychotic, not an antidepressant.
The use of information technology for quality improvement in pharmacotherapeutics includes:
- A. Incorporating the use of 'apps' into all patient encounters
- B. Tracking data trends within the practice via the electronic health record database
- C. Informing patients that they have access to their medication list via the Internet
- D. Using macros for individualizing patient care management
Correct Answer: B
Rationale: Tracking data trends in EHRs supports quality improvement in pharmacotherapeutics.
Human papillomavirus (HPV) vaccine (Gardasil, Cervarix):
- A. Is a live virus vaccine that provides immunity to six strains of HPV virus
- B. Has a common adverse effect of syncope within 15 minutes of giving the vaccine
- C. Should not be given to males younger than age 12 years
- D. May be given to pregnant women
Correct Answer: B
Rationale: HPV vaccine commonly causes syncope post-injection; it's not live , is approved for males 9+ , and is avoided in pregnancy .
A patient tells the clinic nurse that he or she has been taking over-the-counter (OTC) Pepcid to relieve acid indigestion for several years. This is the first time the patient has ever reported this issue to a health care provider. As part of the teaching plan for this patient, the nurse explains what risk associated with not sharing OTC drug use with the provider?
- A. The OTC drug could be more expensive than seeking health care advice.
- B. The drug could mask symptoms of a serious problem that is undiagnosed.
- C. Use of the drug could cause a rebound effect of Pepcid.
- D. The drug could interact with several cold medicines.
Correct Answer: B
Rationale: OTC drugs allow patients to self-diagnose and treat routine signs and symptoms without seeing a health care provider. This self-prescribed treatment, however, could mask a more serious underlying medical problem and result in a poor outcome for the patient. The issues of drug rebound and drug interaction need to be considered, but the safety issue related to self-diagnosis and self-prescription presents the greatest risk to the patient. Patients should always be encouraged to discuss the use of OTC products with their health care provider.
The mean weight of 500 college students is 70 kg and the standard deviation is 3 kg. Assuming that the weight is normally distributed, determine how many students weigh 64 kg or less.
- A. 5
- B. 11
- C. 15
- D. 20
Correct Answer: B
Rationale: P(X ≤ 64) equals P(X < 64) in a continuous distribution since P(X=64) = 0. From the previous calculation, P(Z < -2) ≈ 0.0228, so 0.0228 * 500 ≈ 11, consistent with the document.