Nokea
What describes a primary use of biologic therapy in cancer treatment?
- A. Protect normal,rapidly reproducing cells of the gastrointestinal system from damage during chemotherapy
- B. Prevent the fatigue associated with chemotherapy and high-dose radiation as seen with bone marrow depression
- C. Enhance or supplement the effects of the host’s immune responses to tumor cells that produce flu-like symptoms
- D. Depress the immune system and circulating lymphocytes as well as increase a sense of well-being by replacing central nervous system deficits
Correct Answer: C
Rationale: Biologic therapy enhances the immune response against tumor cells, often causing flu-like symptoms.
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What is the primary role of phagocytosis in innate immunity?
- A. Killing cancer cells
- B. Engulfing and digesting pathogens
- C. Producing antibodies
- D. Activating complement proteins
Correct Answer: B
Rationale: The primary role of phagocytosis in innate immunity is to engulf and digest pathogens. Phagocytes such as macrophages and neutrophils recognize and engulf bacteria, viruses, and other harmful substances to prevent infections. They digest these pathogens using enzymes and destroy them. This process is crucial in the initial defense against infections. Option A is incorrect because phagocytosis primarily targets pathogens, not cancer cells. Option C is incorrect because producing antibodies is a function of adaptive immunity, not innate immunity. Option D is incorrect because activating complement proteins is a separate mechanism in the immune response.
A patient with systemic lupus erythematosus (SLE) is admitted to the hospital for evaluation and management of acute joint inflammation. Which information obtained in the admission laboratory testing concerns you most?
- A. The blood urea nitrogen (BUN) level is elevated.
- B. The C-reactive protein (CRP) level is increased.
- C. The anti-nuclear antibody (ANA) test is positive.
- D. The lupus erythematosus (LE) cell prep is positive.
Correct Answer: A
Rationale: An elevated BUN level may indicate kidney involvement which is a serious complication of SLE. The other findings are expected in SLE and do not indicate an urgent problem. CRP is a marker of inflammation and positive ANA and LE cell prep are diagnostic of SLE but do not indicate acute complications.
A patient had a complicated vaginal hysterectomy. The student nurse provided perineal care after the patient had a bowel movement. The student nurse tells the nurse there was a lot of light brown, smelly drainage seeping from the perianal area. What should the nurse suspect when assessing this patient?
- A. Dehiscence
- B. Hemorrhage
- C. Keloid formation
- D. Fistula formation
Correct Answer: D
Rationale: Fistula formation involves abnormal connections between organs or tissues, often caused by infection or trauma. Light brown, smelly drainage suggests communication between the bowel and skin, indicative of a fistula.
What chemical in poison ivy is responsible for triggering contact dermatitis?
- A. Histamine
- B. Urushiol oil
- C. Lipopolysaccharide (LPS)
- D. C3a
Correct Answer: B
Rationale: The correct answer is B: Urushiol oil. Urushiol oil is the allergen in poison ivy that triggers contact dermatitis. When urushiol oil comes into contact with the skin, it can cause an allergic reaction leading to redness, itching, and inflammation. Histamine (choice A) is a compound released by the body in response to allergens but is not the specific chemical in poison ivy. Lipopolysaccharide (LPS) (choice C) is a component of the outer membrane of certain bacteria and not present in poison ivy. C3a (choice D) is a complement protein involved in the immune response but not related to poison ivy dermatitis.
The release of IL-8 at an infection site specifically induces
- A. Increase of adhesion molecules on local endothelial cells
- B. Local recruitment of neutrophils
- C. Systemic effects, including fever
- D. Increase of acute-phase proteins
Correct Answer: B
Rationale: The correct answer is B because IL-8 is a chemokine that specifically functions to recruit neutrophils to the site of infection. Neutrophils are crucial for fighting off pathogens. A: Increase of adhesion molecules on local endothelial cells is not directly induced by IL-8. C: Systemic effects, including fever, are typically mediated by other cytokines like IL-1 and IL-6. D: Increase of acute-phase proteins is not the primary role of IL-8 in the immune response.