Nokea
What is the immunologic term to indicate the process that eliminates developing T cells whose T-cell receptors bind too strongly to self-peptide/MHC complexes?
Correct Answer: A
Rationale: Negative selection is the correct answer because it refers to the process that eliminates developing T cells with high affinity for self-peptide/MHC complexes to prevent autoimmune reactions. During negative selection, T cells that bind too strongly to self-antigens are deleted or rendered functionally inactive. This ensures that only T cells with moderate affinity for self-antigens are allowed to mature and participate in immune responses.
Summary of other choices:
B: Positive selection involves the selection of T cells that can recognize self-peptide/MHC complexes, promoting their maturation and survival.
C: Peripheral tolerance refers to mechanisms that maintain self-tolerance in the mature immune system, not specifically related to eliminating self-reactive T cells during development.
D: Lineage commitment is the process by which precursor cells differentiate into specific immune cell types and is not directly related to eliminating self-reactive T cells.