Review of Systems Neurological Questions Related

Review Review of Systems Neurological Questions related questions and content

What is the relationship between dorso-ventral patterning of the neural tube and patterning of the somites?

  • A. The somites pattern the neural tube after they form.
  • B. The neural tube plays the role of organizer in being the sole influence on patterning in the somites
  • C. Sonic hedgehog from the notochord and floorplate of the neural tube confers ventral fates on both the neural tube and the somite, while BMPs confer more dorsal fates.
  • D. Both the neural tube and the somites acquire their dorso-ventral patterning during gastrulation
Correct Answer: C

Rationale: Dorso-ventral patterning of the neural tube and somites is regulated by opposing gradients of Sonic hedgehog (Shh) from the notochord and floorplate (ventralizing signals) and BMPs from the dorsal neural tube (dorsalizing signals). These signals coordinate the development of both structures, ensuring proper alignment and function of the nervous system and musculoskeletal system.