Nokea
When administering an intradermal injection, the nurse would use a 1-mL syringe with which gauge of needle? Select one that does not apply.
- A. 26 gauge
- B. 27 gauge
- C. 29 gauge
- D. 25 gauge
Correct Answer: C
Rationale: A 1-mL syringe with a 25- to 27-gauge needle that is 1/4 to 5/8 inches long is best suited for intradermal injections.
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Digoxin is a drug that has been used to treat systolic heart failure for over 200 years. It has a therapeutic index value of 2. How many daily doses of digoxin will the average patient have to take at one time to have a 50:50 chance of developing toxic side effects?
- A. One
- B. Two
- C. I don't know
Correct Answer: B
Rationale: With a therapeutic index of 2, the toxic dose is twice the therapeutic dose. Taking two daily doses at once would reach this threshold, giving a 50:50 chance of toxicity.
All of following drugs are metabolized in body by acetylation except:
- A. INH
- B. Hydralazine
- C. Procainamide
- D. Dilantin
Correct Answer: D
Rationale: Dilantin (phenytoin) is metabolized by hydroxylation, not acetylation.
Protein binding of a drug helps in
- A. Distribution
- B. Prolonging half life
- C. Limiting metabolism
- D. All of the above
Correct Answer: D
Rationale: Protein binding affects distribution (bound drugs stay in plasma), prolongs half-life (less free drug available for clearance), and limits metabolism (bound drug is less accessible to enzymes).
Least half life is for which hormone
- A. Nor adrenaline
- B. Renin
- C. Aldosterone
- D. Thyroxine
Correct Answer: A
Rationale: Noradrenaline has a very short half-life (minutes) due to rapid metabolism.
What describes the action of the body on the drug?
- A. Pharmacodynamics
- B. Pharmacokinetics
- C. Microbiology
- D. Physiology
Correct Answer: B
Rationale: Pharmacokinetics describes how the body affects a drug, including absorption, distribution, metabolism, and excretion, distinct from pharmacodynamics, which is the drug's effect on the body.