Chronic Disease Questions Related

Review Chronic Disease Questions related questions and content

When using induced hypotension during orthognathic surgery:

  • A. Mean arterial blood pressure may be reduced to 30% of normal in patients of ASA grade I.
  • B. The stress response to surgery is attenuated.
  • C. Drugs that cause relative bradycardia are useful adjuncts.
  • D. The desired effects of clonidine are mediated by α₁-adrenoceptors.
Correct Answer: C

Rationale: Induced hypotension in orthognathic surgery reduces bleeding, enhancing visibility. Mean arterial pressure (MAP) drops to 50-65 mmHg (not 30% of normal, ~20-25 mmHg, which risks ischemia), safe in ASA I patients with monitoring. Stress response attenuation occurs with deep anaesthesia, not hypotension alone. Bradycardia-inducing drugs (e.g., β-blockers, remifentanil) stabilize haemodynamics, aiding controlled hypotension by lowering cardiac output safely. Clonidine, an α₂-agonist (not α₁), reduces sympathetic outflow, supporting hypotension and sedation. Invasive monitoring mitigates pressure injury risk. Bradycardia's role enhances technique precision, minimizing transfusion needs while maintaining perfusion in healthy patients.