Nokea
Which aminoglycoside is most commonly used in the treatment of cystic fibrosis patients infected with Pseudomonas aeruginosa?
- A. Amikacin
- B. Streptomycin
- C. Tobramycin
- D. Gentamicin
Correct Answer: C
Rationale: Tobramycin is frequently used in cystic fibrosis patients for its efficacy against Pseudomonas aeruginosa, often administered via inhalation or IV.
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Which of the following is biguanide:
- A. Glibenclamide
- B. Metformin
- C. Acarbose
- D. Liraglutide
Correct Answer: B
Rationale: Metformin is a biguanide that reduces hepatic glucose output.
What concept is considered when generic drugs are substituted for brand name drugs?
- A. Bioavailability
- B. Critical concentration
- C. Distribution
- D. Half-life
Correct Answer: A
Rationale: Bioavailability is the portion of a dose of a drug that reaches the systemic circulation and is available to act on body cells. Binders used in a generic drug may not be the same as those used in the brand name drug. Therefore, the way the body breaks down and uses the drug may differ, which may eliminate a generic drug substitution. Critical concentration is the amount of a drug that is needed to cause a therapeutic effect and should not differ between generic and brand name medications. Distribution is the phase of pharmacokinetics, which involves the movement of a drug to the body's tissues and is the same in generic and brand name drugs. A drug's half-life is the time it takes for the amount of drug to decrease to half the peak level, which should not change when substituting a generic medication.
Patients who are on chronic long-term corticosteroid therapy need education regarding:
- A. Receiving all vaccinations, especially the live flu vaccine
- B. Reporting black tarry stools or abdominal pain
- C. Eating a high carbohydrate diet with plenty of fluids
- D. Small amounts of alcohol are generally tolerated
Correct Answer: B
Rationale: Black tarry stools signal GI bleeding from corticosteroids; live vaccines are contraindicated.
During what phase of the nursing process would the nurse be required to consider the efficacy of nursing interventions related to drug therapy?
- A. Assessment
- B. Nursing diagnosis
- C. Interventions
- D. Evaluation
Correct Answer: D
Rationale: Evaluation phase assesses the effectiveness of interventions, including those related to drug therapy.
The following drugs can be used for treatment of diabetes except one:
- A. Insulines
- B. Biguanides
- C. alfa glucosidase inhibitors
- D. Glucagon
Correct Answer: D
Rationale: Glucagon increases blood glucose levels by promoting glycogenolysis and gluconeogenesis, making it unsuitable for diabetes treatment, unlike the others which lower glucose.