FNP Pediatric Practice Questions Related

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Which antiparkinsonian drug is associated with the on-off phenomenon and the wearing-off effect?

  • A. Amantadine
  • B. Levodopa
  • C. Benztropine
  • D. Pramixole
Correct Answer: B

Rationale: Levodopa is the antiparkinsonian drug associated with the on-off phenomenon and the wearing-off effect. The on-off phenomenon refers to the sudden and unpredictable fluctuations between periods of symptom control (on) and periods of symptom re-emergence (off) in patients with Parkinson's disease receiving levodopa therapy. This can happen as the disease progresses and the brain becomes less responsive to the medication.