Nokea
Which condition is associated with granulomas?
- A. Crohn's disease
- B. Grave's disease
- C. Anaphylaxis
- D. Eczema
Correct Answer: A
Rationale: The correct answer is A: Crohn's disease. Granulomas are a characteristic feature of Crohn's disease, forming in response to chronic inflammation in the gastrointestinal tract. Granulomas consist of immune cells and are seen in the affected tissues of Crohn's patients.
Choice B: Grave's disease is an autoimmune condition affecting the thyroid gland, not typically associated with granulomas.
Choice C: Anaphylaxis is a severe allergic reaction involving the immune system's response, but it does not lead to granuloma formation.
Choice D: Eczema is a skin condition characterized by inflammation and itching, but it does not typically involve granulomas.
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Which of the following about Influenza virus is NOT correct
- A. It's an RNA virus
- B. In humans influenza infects the lung epithelial cells
- C. Release of newly formed virus from the infected cell is mediated by Hemagglutinin (HA)
- D. Tamiflu is a Neuraminidase (NA) inhibitor
Correct Answer: C
Rationale: The correct answer is C because the release of newly formed virus from the infected cell is actually mediated by Neuraminidase (NA), not Hemagglutinin (HA).
1. Influenza virus is indeed an RNA virus (Choice A).
2. In humans, influenza primarily infects lung epithelial cells (Choice B).
3. Hemagglutinin (HA) helps the virus enter host cells, while Neuraminidase (NA) helps release viral particles from infected cells (Choice C is incorrect).
4. Tamiflu is a Neuraminidase (NA) inhibitor, which prevents the release of viral particles, aiding in the treatment of influenza infections (Choice D).
One principal function of the Class I and Class II major histocompatibility complex S proteins is to
- A. transduce the signal to the T-cell interior following antigen binding
- B. mediate immunoglobulin class switching
- C. present antigen for recognition by the T-cell antigen receptor
- D. stimulate production of interleukins
Correct Answer: C
Rationale: The correct answer is C because Class I and Class II MHC proteins present antigens to T-cell receptors for immune response activation. Class I MHC presents endogenous antigens to CD8+ T cells, while Class II MHC presents exogenous antigens to CD4+ T cells. Choice A is incorrect because MHC proteins do not transduce signals. Choice B is incorrect because MHC proteins do not mediate immunoglobulin class switching. Choice D is incorrect because MHC proteins do not directly stimulate interleukin production.
Which of the following statement is incorrect
- A. Antigens in tissues can reach regional LN via afferent lymphatic vessels
- B. Migrating dendritic cells that have collected antigens in tissues enter the draining LN via HEV
- C. During an infection fever and other inflammatory signals induce increased blood flow to draining LN and increased chances for lymphocytes to migrate from blood into LN
- D. The thoracic duct returns most of the circulating lymphocytes back to blood
Correct Answer: B
Rationale: The correct answer is B because migrating dendritic cells do not enter the draining lymph node (LN) via high endothelial venules (HEV); instead, they enter through afferent lymphatic vessels. HEVs are specialized post-capillary venules in LN where lymphocytes enter from the bloodstream. Dendritic cells, carrying antigens from tissues, travel via afferent lymphatic vessels to reach the LN where they present antigens to lymphocytes. Option A is correct as antigens in tissues reach LN via afferent lymphatic vessels. Option C is correct as infection-induced signals can increase blood flow to LN, facilitating lymphocyte migration. Option D is incorrect because the thoracic duct returns lymph back to the bloodstream, not specifically lymphocytes.
Pattern recognition receptors (PRR) can be found
- A. In soluble form in the blood
- B. In the cytosol of cells
- C. On endosomal membranes
- D. All of the above are correct
Correct Answer: D
Rationale: Pattern recognition receptors (PRRs) are a class of receptors that recognize specific molecular patterns associated with pathogens. They can be found in various locations within the body, including in soluble form in the blood (Choice A), in the cytosol of cells (Choice B), and on endosomal membranes (Choice C). Therefore, the correct answer is D, "All of the above are correct," as PRRs can indeed be located in all of these locations. PRRs play a crucial role in the innate immune response by detecting and responding to pathogens, making their presence in multiple cellular compartments essential for effective immune surveillance and defense.
Lysozyme is NOT
- A. An enzyme present in secretions and tears
- B. A type of Defensin
- C. Part of the chemical innate barriers to infection
- D. A protein capable of dissolving the cell wall of bacteria
Correct Answer: B
Rationale: The correct answer is B because lysozyme is not a type of defensin. Lysozyme is an enzyme present in secretions and tears, part of chemical innate barriers to infection, and capable of dissolving the cell wall of bacteria. Defensins are a different type of antimicrobial peptides that function by disrupting the microbial cell membrane. Therefore, B is the correct answer as it does not accurately describe lysozyme's function.