Nokea
Which is not a PAMP?
- A. Viral dsRNA
- B. Peptidoglycan
- C. ROS
- D. Flagellin
Correct Answer: C
Rationale: The correct answer is C: ROS (Reactive Oxygen Species) is not a PAMP (Pathogen-Associated Molecular Pattern) because it is not a specific molecular pattern derived from pathogens. PAMPs are recognized by the innate immune system to trigger an immune response. Viral dsRNA, peptidoglycan, and flagellin are all examples of PAMPs as they are specific molecules commonly found in pathogens that can be recognized by pattern recognition receptors (PRRs) on immune cells, leading to activation of the immune response.ROS, on the other hand, are reactive molecules produced by host cells in response to pathogens but are not specific molecular patterns derived from pathogens. Therefore, ROS is not considered a PAMP.
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When assessing a patient for anaphylaxis, be alert for:
- A. Chest pain and indigestion.
- B. Hives and dyspnea.
- C. Hypertension and blurred vision.
- D. Headache and photophobia.
Correct Answer: B
Rationale: Anaphylaxis typically presents with symptoms such as hives (skin reaction) and dyspnea (difficulty breathing), which are indicative of an allergic response affecting the airways and skin. Hypertension and blurred vision are not typical signs of anaphylaxis.
Which antibody dominates the primary immune response?
- A. IgG
- B. IgA
- C. IgM
- D. IgE
Correct Answer: C
Rationale: The correct answer is C: IgM. During the primary immune response, IgM is the first antibody produced by the immune system in response to an antigen. IgM is efficient in agglutination and complement fixation, aiding in the elimination of pathogens. IgG is more prominent in the secondary immune response. IgA is mainly found in mucosal areas. IgE is associated with allergic reactions and parasitic infections, not the primary immune response. So, IgM dominates the primary immune response by being the initial antibody produced to combat antigens.
Which of the following is a physical barrier provided by innate immunity?
- A. Antibodies
- B. T lymphocytes
- C. Tight junctions in epithelial cells
- D. Phagocytosis
Correct Answer: C
Rationale: The correct answer is C: Tight junctions in epithelial cells. These junctions physically prevent pathogens from entering the body. Antibodies (A) and T lymphocytes (B) are components of adaptive immunity, not physical barriers. Phagocytosis (D) is a cellular process, not a physical barrier.
To what is the increase in emerging and untreatable infections attributed (select all that apply)?
- A. The evolution of new infectious agents
- B. Use of antibiotics to treat viral infections
- C. Human population encroachment into wilderness areas
- D. Transmission of infectious agents from humans to animals
Correct Answer: A
Rationale: The correct answer includes options A, B, C, and E. The evolution of new infectious agents, inappropriate use of antibiotics, human encroachment into wilderness areas, and an increased number of immunosuppressed individuals contribute significantly to the rise in untreatable infections. Transmission from humans to animals is less relevant compared to zoonotic transmission from animals to humans.
Which of the statements below is NOT true. Integration is a stage of HIV life cycle that
- A. Utilizes a host enzyme called integrase
- B. Is a target of some anti-HIV drugs
- C. Allows duplication of proviral DNA when the infected cell divides
- D. Requires the formation of double stranded DNA
Correct Answer: A
Rationale: The correct answer is A. Integration is a stage of HIV life cycle that involves the insertion of viral DNA into the host cell's genome, facilitated by the enzyme integrase. To explain why A is incorrect, integrase is a viral enzyme, not a host enzyme.
B is correct as some anti-HIV drugs target the integration stage to prevent viral replication.
C is correct as integrated proviral DNA allows for duplication during cell division.
D is correct as integration requires the formation of double-stranded viral DNA.