Nokea
Which of the following drugs for treatment of leprosy can cause hemolysis especially in patients with G6PD deficiency?
- A. Dapsone
- B. Rifampicin
- C. Clofazimine
- D. None of these
Correct Answer: A
Rationale: The correct answer is A: Dapsone. Dapsone is known to cause hemolysis in patients with G6PD deficiency due to oxidative stress. G6PD deficiency leads to reduced ability to protect red blood cells from oxidative damage, which can be exacerbated by drugs like dapsone. Rifampicin and clofazimine are not associated with hemolysis in G6PD deficient patients. Option D is incorrect as dapsone is known to cause hemolysis in this population.
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What does the dialysate for PD routinely contain?
- A. Calcium in a lower concentration than in the blood
- B. Sodium in a higher concentration than in the blood
- C. Dextrose in a higher concentration than in the blood
- D. Electrolytes in an equal concentration to that of the blood
Correct Answer: C
Rationale: Correct Answer: C - Dextrose in a higher concentration than in the blood
Rationale:
1. Dextrose in PD dialysate helps to create an osmotic gradient for fluid removal.
2. Higher dextrose concentration ensures effective ultrafiltration.
3. Dextrose is the main osmotic agent used in PD.
4. A higher concentration of dextrose in the dialysate aids in waste removal.
Summary:
A: Incorrect - Calcium concentration in dialysate is similar to blood to avoid imbalance.
B: Incorrect - Sodium concentration is lower in dialysate to prevent sodium loading.
D: Incorrect - Electrolyte concentration in dialysate is tailored to patient needs, not equal to blood.
The first step in urine production
- A. is called reabsorption.
- B. moves water and solutes from the renal tubules into the peritubular capillaries.
- C. is called secretion.
- D. occurs as water and solutes move from the glomerulus to the glomerular capsul
Correct Answer: D
Rationale: The correct answer is D because the first step in urine production occurs as water and solutes move from the glomerulus to the glomerular capsule during the process of filtration. This initial step involves the passive movement of water and small solutes through the filtration membrane in the glomerulus. Reabsorption (choice A) occurs later in the process when useful substances are reclaimed from the filtrate. Choice B is incorrect as it describes the process of reabsorption, not the initial step. Choice C is also incorrect as secretion is the process of actively transporting substances from the blood into the renal tubules, not the first step in urine production.
The female gonad is called a(n)
- A. placenta
- B. fallopian tube
- C. fimbria
- D. ovary
Correct Answer: D
Rationale: The correct answer is D: ovary. The female gonad is the primary reproductive organ that produces eggs and secretes hormones. The ovary is specifically responsible for these functions. Placenta (A) is an organ formed during pregnancy, fallopian tube (B) is a part of the female reproductive system that transports eggs, and fimbria (C) are finger-like projections at the end of the fallopian tube. Therefore, the ovary is the only choice that accurately represents the female gonad.
Which antibiotic course is inappropriate for clinical scenario?
- A. Acute simple cystitis - trimethoprim for 3 days in otherwise well young women.
- B. Acute uncomplicated pyelonephritis - gentamycin + amoxicillin IV initially followed by 7 days of Augmentin orally.
- C. Pregnancy associated cystitis - nitrofurantoin 5 mg QID for 14 days.
- D. Acute simple cystitis in male patients - Augmentin or trimethoprim for 14 days.
Correct Answer: B
Rationale: The correct answer is B because the antibiotic regimen for acute uncomplicated pyelonephritis should not include gentamycin due to its potential toxicity and nephrotoxicity. The initial use of IV gentamycin is not recommended for uncomplicated pyelonephritis. The combination of gentamycin and amoxicillin is not the standard treatment for this condition. Gentamycin should be reserved for more serious infections. The choice of Augmentin for 7 days orally is also not the standard of care for pyelonephritis. The other choices (A, C, D) are appropriate antibiotic regimens for the corresponding clinical scenarios.
A patient with severe infectious disease is being treated with aminoglycoside antibiotics. Which of the following diuretic should be avoided for this patient because of the serious side effect shared by both drugs?
- A. Furosemide
- B. Hydrochlorothiazide
- C. Spironolactone
- D. Acetazolamide
Correct Answer: A
Rationale: The correct answer is A: Furosemide. Aminoglycoside antibiotics can cause ototoxicity and nephrotoxicity. Furosemide, a loop diuretic, also has the potential to cause ototoxicity and nephrotoxicity. Therefore, combining aminoglycosides with furosemide can increase the risk of these serious side effects.
B: Hydrochlorothiazide is a thiazide diuretic that does not share the same severe side effects as aminoglycosides.
C: Spironolactone is a potassium-sparing diuretic and does not have the same side effects as aminoglycosides.
D: Acetazolamide is a carbonic anhydrase inhibitor diuretic and does not share the same severe side effects as aminoglycosides.