Nokea
Which of the following is biguanide:
- A. Glibenclamide
- B. Metformin
- C. Acarbose
- D. Liraglutide
Correct Answer: B
Rationale: Metformin is a biguanide that reduces hepatic glucose output.
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Vera, age 70, has isolated systolic hypertension. Calcium channel blocker dosages for her should be:
- A. Started at about half the usual dosage
- B. Not increased over the usual dosage for an adult
- C. Given once daily because of memory issues in the older adult
- D. Withheld if she experiences gastroesophageal reflux
Correct Answer: A
Rationale: Elderly patients start at half dose due to reduced metabolism and clearance.
In deciding which of multiple drugs used to use to treat a condition, the NP chooses Drug A because it:
- A. Has serious side effects and it is not being used for a life-threatening condition
- B. Will be taken twice daily and will be taken at home
- C. Is expensive, but covered by health insurance
- D. None of these are important in choosing a drug
Correct Answer: B
Rationale: Choosing a drug taken twice daily at home reflects practical considerations like adherence, outweighing side effects or cost alone . All factors matter (D is false).
Which statement accurately describes a drug agonist?
- A. A drug that reacts with specific receptor sites on a cell and prevents the reaction of another chemical with a different receptor site on that cell
- B. A drug that interferes with the enzyme systems that act as catalysts for different chemical reactions
- C. A drug that interacts directly with receptor sites to cause the same activity that a natural chemical would cause at that site
- D. A drug that reacts with receptor sites to block normal stimulation, producing no effect
Correct Answer: C
Rationale: Agonists are drugs that produce effects similar to those produced by naturally occurring neurotransmitters, hormones, or other substances found in the body. Noncompetitive antagonists are drugs that react with certain receptor sites, preventing the reaction of another chemical with a different receptor site. Drug-enzyme interactions interfere with the enzyme systems that stimulate various chemical reactions.
Pregnant patients who are taking isoniazid (INH) should take 25 mg/day of vitamin B6 (pyridoxine) to prevent:
- A. Beriberi
- B. Peripheral neuropathy
- C. Rickets
- D. Megaloblastic anemia
Correct Answer: B
Rationale: Vitamin B6 supplementation prevents INH-induced peripheral neuropathy.
Isoproterenol produces maximal contraction of cardiac muscle in a manner similar to epinephrine. Which of the following best describe isoproterenol?
- A. Fuller agonist
- B. Partial agonist
- C. Irreversible antagonist
- D. Inverse agonist
Correct Answer: A
Rationale: Isoproterenol's maximal effect similar to epinephrine indicates it is a full agonist at beta receptors.