Nokea
Which of the following is NOT true of cortisol?
- A. It counteracts the inflammatory response.
- B. It promotes the breakdown of proteins to amino acids that the liver uses to convert to glucose.
- C. It promotes metabolism of fatty acids instead of glucose.
- D. It is a mineralocorticoid.
Correct Answer: D
Rationale: Correct Answer: D - It is a mineralocorticoid.
Rationale: Cortisol is a glucocorticoid, not a mineralocorticoid. Glucocorticoids like cortisol regulate glucose metabolism and counteract inflammation, supporting options A and B. Option C is also incorrect as cortisol promotes the metabolism of glucose over fatty acids.
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A patient presents with a moon face, truncal obesity, hypertension, purple straiae, buffalo hump, fragile skin and impaired glucose tolerance. The opposite of the current increased levels of the prime hormone involved in this patient is seen in:
- A. Addison's disease
- B. Pheochromocytoma
- C. Hyperaldosteronism
- D. Cushing's syndrome
Correct Answer: A
Rationale: Step 1: Identify the symptoms described in the patient: Moon face, truncal obesity, hypertension, purple striae, buffalo hump, fragile skin, impaired glucose tolerance.
Step 2: These symptoms are classic for Cushing's syndrome, which is caused by excess cortisol.
Step 3: The opposite of increased cortisol levels is decreased cortisol levels.
Step 4: Addison's disease is characterized by adrenal insufficiency, leading to decreased cortisol levels.
Step 5: Therefore, the correct answer is A: Addison's disease.
Summary:
- B: Pheochromocytoma is a tumor of the adrenal medulla, causing excess catecholamines, not related to cortisol.
- C: Hyperaldosteronism is excess aldosterone production, not related to cortisol.
- D: Cushing's syndrome is characterized by excess cortisol, not the opposite.
Which artery generally gives rise to inferior thyroid artery?
- A. External carotid artery
- B. Internal carotid artery
- C. Brachiocephalic trunk
- D. Thyrocervical trunk
Correct Answer: D
Rationale: Step-by-step rationale:
1. The inferior thyroid artery typically arises from the thyrocervical trunk.
2. The thyrocervical trunk is a branch of the subclavian artery.
3. This artery supplies blood to the thyroid gland.
4. The external carotid artery and internal carotid artery do not give rise to the inferior thyroid artery.
5. The brachiocephalic trunk does not directly supply blood to the thyroid gland.
In conclusion, the correct answer is D because the thyrocervical trunk is the main artery that gives rise to the inferior thyroid artery, providing blood supply to the thyroid gland.
A morbidly obese person visits the local bariatric (weight loss) clinic seeking a pill that will help shed weight. The physician prescribes dextroamphetamine. In addition to causing its expected centrally mediated anorexigenic (appetite-suppressant) effects, it causes a host of peripheral adrenergic effects that, for some patients, can prove fatal. The main mechanism by which dextroamphetamine or amphetamines in general, cause their peripheral autonomic effects is
- A. Activates MAO
- B. Blocks NE reuptake via the amine pump/transporter
- C. Displaces, releases, intraneuronal NE
- D. Enhances NE synthesis, leading to massive neurotransmitter overproduction
Correct Answer: C
Rationale: Rationale for Correct Answer (C): Dextroamphetamine causes peripheral adrenergic effects by displacing, releasing, intraneuronal NE. Amphetamines disrupt the storage and release of NE from intraneuronal vesicles, leading to an increase in synaptic NE levels. This excess NE can stimulate adrenergic receptors in the periphery, causing adverse effects like hypertension, tachycardia, and potentially fatal outcomes.
Summary of Incorrect Choices:
A: Activating MAO would increase NE breakdown, not cause peripheral adrenergic effects.
B: Blocking NE reuptake would increase NE levels in the synapse, not intraneuronally, leading to central effects.
D: Enhancing NE synthesis would not directly lead to peripheral adrenergic effects, as it would require release and action at the synapse.
The hormone involved in rhythmic activities, such as day/night and seasonal changes, is .
- A. calcitonin
- B. melatonin
- C. estrogen
- D. cyclin
Correct Answer: B
Rationale: The correct answer is B: melatonin. Melatonin is the hormone involved in regulating rhythmic activities like day/night and seasonal changes through its influence on the body's circadian rhythm. Calcitonin is a hormone that regulates calcium levels in the blood; estrogen is a female sex hormone; and cyclin is a protein involved in cell cycle regulation. Melatonin's role in regulating sleep-wake cycles and responding to changes in light exposure makes it the most appropriate choice for a hormone involved in rhythmic activities.
In the emergency department, during initial assessment of a new admission with diabetes, you discover all of the following. Which information should you immediately report to the physician?
- A. Hammertoe of the left second metatarsophalangeal joint
- B. Rapid respiratory rate with deep inspirations
- C. Numbness and tingling bilaterally in feet and hands
- D. Decreased sensitivity and swelling of the abdomen
Correct Answer: B
Rationale: Rapid respiratory rate with deep inspirations may indicate diabetic ketoacidosis (DKA) or another metabolic disturbance and requires immediate intervention.