Nokea
Which of the following medications has not hypoglycemic effect:
- A. Insulin
- B. Glucagon
- C. Metformin
- D. Glibenclamid
Correct Answer: B
Rationale: Glucagon raises blood glucose levels, unlike the others which lower it.
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A nurse working for a drug company is involved in phase III drug evaluation studies. Which of the following might the nurse be responsible for during this stage of drug development?
- A. Working with animals who are given experimental drugs
- B. Monitoring drug effects in patients who are selected to participate in a study, who have the disease that the drug is meant to treat
- C. Collecting records of symptoms that participants experience while taking a drug and determining whether they are caused by the disease or the drug
- D. Informing healthy, young volunteer participants of possible risks that could occur from taking an experimental drug
Correct Answer: C
Rationale: Phase III studies involve use of a drug in a vast clinical market where patients are asked to record any symptoms they experience while taking the drugs. Nurses may be responsible for helping collect and analyze the information to be shared with the Food and Drug Administration (FDA). Use of animals in drug testing is done in the preclinical trials. A select group of patients who are involved in phase II studies participate in studies where the participants have the disease the drug is intended to treat. These patients are monitored closely for drug effects. Phase I studies involve healthy human volunteers who are usually paid for their participation. Nurses may observe for adverse effects and toxicity.
All are explained on pharmacogenetic conditions except
- A. G6PD deficiency
- B. Warfarin insensitivity
- C. Adenosine deaminase deficiency
- D. Malignant hyperthermia
Correct Answer: C
Rationale: Adenosine deaminase deficiency is not typically pharmacogenetic; others are.
Which of the following NSAIDs has greater inhibitory selectivity for COX-1 than COX-2?
- A. Flurbiprofen
- B. Indomethacin
- C. Diclofenac
- D. Celecoxib
Correct Answer: B
Rationale: Indomethacin is more selective for COX-1, whereas celecoxib is COX-2 selective; others have mixed activity.
The routine monitoring recommended for low molecular weight heparin is:
- A. INR every 2 days until stable, then weekly
- B. aPTT every week while on therapy
- C. Factor Xa levels if the patient is pregnant
- D. White blood cell count every 2 weeks
Correct Answer: C
Rationale: Factor Xa levels may be monitored in pregnancy with LMWH; routine INR or aPTT isn't needed due to predictable pharmacokinetics.
A nurse reviewing a client's health record notes a new prescription for Lisinopril 10 mg PO once every day. The nurse should identify this as which of the following types of prescription?
- A. Single
- B. Stat
- C. Routine
- D. Standing
Correct Answer: C
Rationale: A daily dose (once every day) indicates a routine prescription for ongoing treatment.