Nokea
Which of the following NSAIDs has greater inhibitory selectivity for COX-1 than COX-2?
- A. Flurbiprofen
- B. Indomethacin
- C. Diclofenac
- D. Celecoxib
Correct Answer: B
Rationale: Indomethacin is more selective for COX-1, whereas celecoxib is COX-2 selective; others have mixed activity.
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Which of the following medications has not hypoglycemic effect:
- A. Insulin
- B. Glucagon
- C. Metformin
- D. Glibenclamid
Correct Answer: B
Rationale: Glucagon raises blood glucose levels, unlike the others which lower it.
A nurse reviewing a client's health record notes a new prescription for Lisinopril 10 mg PO once every day. The nurse should identify this as which of the following types of prescription?
- A. Single
- B. Stat
- C. Routine
- D. Standing
Correct Answer: C
Rationale: A daily dose (once every day) indicates a routine prescription for ongoing treatment.
The patient is taking a drug that affects the body by increasing cellular activity. Where does this drug work on the cell?
- A. Receptor sites
- B. Cell membrane
- C. Golgi body
- D. Endoplasmic reticulum
Correct Answer: A
Rationale: Many drugs are thought to act at specific areas on cell membranes called receptor sites. After the receptor site is activated, this in turn activates the enzyme systems to produce certain effects, such as increased or decreased cellular activity, changes in cell membrane permeability, or alterations in cellular metabolism. Receptor sites are generally located on the outside of cells and allow the drug to bypass the cell membrane. The Golgi body and endoplasmic reticulum are not involved in this process.
A nurse is caring for a client who has a new prescription for Phenelzine for the treatment of depression. Which of the following indicates that the client has developed an adverse effect of this medication?
- A. Orthostatic hypotension
- B. Hearing loss
- C. Gastrointestinal bleeding
- D. Weight loss
Correct Answer: A
Rationale: Phenelzine, an MAOI, commonly causes orthostatic hypotension due to its effect on blood pressure regulation.
Which topical antifungal medication is used to treat vaginal candidiasis?
- A. Haloprogin (Halotex)
- B. Miconazole (Monistat)
- C. Oxiconazole (Oxistat)
- D. Terbinafine HCl (Lamisil)
Correct Answer: B
Rationale: Miconazole is a standard topical treatment for vaginal candidiasis; others target skin infections. Topical miconazole is used to treat vaginal candidiasis.