Gastrointestinal Practice Questions Related

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Which of the following statements is TRUE? The protein FOXO1:

  • A. activates (increases the expression of) genes related to greater longevity
  • B. is activated by caloric restriction
  • C. is deactivated by increased insulin signalling
  • D. all of the above are true
Correct Answer: D

Rationale: Step-by-step rationale:
1. FOXO1 activates genes related to greater longevity by regulating stress responses and promoting cell survival.
2. Caloric restriction activates FOXO1 to promote cellular stress resistance and increase lifespan.
3. Increased insulin signaling deactivates FOXO1, leading to decreased stress resistance and potentially shorter lifespan.
4. Therefore, all the statements (A, B, and C) are true regarding the protein FOXO1. It plays a crucial role in longevity through gene regulation, is activated by caloric restriction, and is deactivated by increased insulin signaling.