Fluid Maintenance Pediatrics Practice Questions Related

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A client has squamous cell cancer of the right lung that has metastasized to the brain. In addition to chemotherapy for lung cancer, the physician prescribes lomustine (CeeNU), 100 mg/m2 as a single dose, to treat the brain metastasis. What are the major administration and excretion routes of lomustine?

  • A. Oral administration and urinary
  • B. I.V. administration and urinary excretion
  • C. I.V administration and fecal excretion
  • D. Oral administration and fecal excretion
Correct Answer: B

Rationale: Lomustine (CeeNU) is typically administered intravenously (I.V.), making choice B the correct administration route. Lomustine is metabolized in the liver and excreted primarily through the kidneys via urine, which accounts for its urinary excretion. Therefore, the major administration route for lomustine is intravenous (I.V.) and the major excretion route is urinary.