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Which one of the following is a fundamental difference between competitive and noncompetitive antagonist?
- A. Competitive and non competitive work on different receptors
- B. Competitive antagonist reduces agonist potency (increase EC50) and non competitive antagonist reduces agonist efficacy (decrease E max)
- C. There is no difference between them, they are exactly the same
- D. Non competitive antagonist causes an upward shift of the E max while competitive antagonist does the opposite
Correct Answer: B
Rationale: Competitive antagonists shift potency (EC50), while noncompetitive reduce efficacy (Emax), a key pharmacological distinction.
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According to Center for Disease Control and Prevention (CDC) recommendations, what is the role of the nurse in preparing for the possibility of bioterrorism?
- A. Post updated information on signs and symptoms of infections caused by biological agents
- B. Provide guidelines for treating patients exposed to, or potentially exposed to, biological agents
- C. Remain current on recognition and treatment of infections caused by biological weapons
- D. Advocate for increased funding for research involving bioterrorism and patient treatment
Correct Answer: C
Rationale: Nurses need to remain current about recognition of and treatment for those exposed to biological weapons because nurses are often called upon to answer questions, reassure the public, offer educational programs, and serve on emergency preparedness committees. The CDC posts updated information on signs and symptoms of infections caused by biological agents that nurses would read. The CDC also provides guidelines for how to treat patients exposed to biological agents and the nurse must remain current on this information. Although nurses could advocate for funding, this is not usually the role of the nurse.
Varicella vaccine is recommended to be given to patients who are:
- A. HIV positive with a CD4+ T-lymphocyte percentage less than 15%
- B. Taking corticosteroids (up to 2 mg/kg/day or less than 20 mg/day)
- C. Pregnant
- D. Immunocompromised
Correct Answer: B
Rationale: Varicella vaccine is safe with low-dose steroids; HIV with low CD4 , pregnancy , or immunocompromise contraindicate it.
You are treating a patient with a diagnosis of Alzheimer's disease. The patient's wife mentions difficulty with transportation to the clinic. Which medication is the best choice?
- A. Donepezil
- B. Tacrine
- C. Doxazosin
- D. Verapamil
Correct Answer: A
Rationale: Donepezil, with once-daily dosing, is practical for patients with transportation issues.
The first-line treatment for cough related to an upper respiratory tract infection (URI) in a 5-year-old child is:
- A. Fluids and symptomatic care
- B. Dextromethorphan and guaifenesin syrup (Robitussin DM for Kids)
- C. Guaifenesin and codeine syrup (Tussin AC)
- D. Chlorpheniramine and dextromethorphan syrup (Nyquil for Kids)
Correct Answer: A
Rationale: Fluids and symptomatic care are safest and recommended for URI cough in young children; cough suppressants are discouraged under 6.
A nurse is teaching the parents of a school-age child about transdermal Methylphenidate. Which of the following instructions should the nurse include?
- A. Apply one patch twice per day.
- B. Leave the patch on for 9 hr.
- C. Apply the patch to the child's waist.
- D. Use opened tray within 6 months.
Correct Answer: B
Rationale: Methylphenidate patches are worn for 9 hours to control ADHD symptoms during the day.