Nokea
You prescribe bromocriptine for a woman with primary amenorrhea. Normal menstruation returns about a month after starting therapy. Which of the following statements best describes the mechanism by which bromocriptine caused its desired effects?
- A. Blocked estrogen receptors, enhanced gonadotropin release
- B. Increased FSH synthesis
- C. Inhibited prolactin release
- D. Stimulated ovarian estrogen and progestin synthesis
Correct Answer: C
Rationale: Bromocriptine, a dopamine agonist, inhibits prolactin, restoring ovulation in hyperprolactinemia.
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A 66-year-old male was prescribed phenelzine (Nardil) while in an acute psychiatric unit for recalcitrant depression. The NP managing his primary health care needs to understand the following regarding phenelzine and other monoamine oxidase inhibitors (MAOIs):
- A. He should not be prescribed any serotonergic drug such as sumatriptan (Imitrex)
- B. MAOIs interact with many common foods, including yogurt, sour cream, and soy sauce
- C. Symptoms of hypertensive crisis (headache, tachycardia, sweating) require immediate treatment
- D. All of the above
Correct Answer: D
Rationale: MAOIs have serotonergic interactions, food restrictions (tyramine), and hypertensive crisis risks.
Commercials on TV for erectile dysfunction (ED) medications warn about mixing them with nitrates. Why?
- A. Increased risk of priapism
- B. Profound hypotension
- C. Development of blue discoloration to the visual field
- D. Inactivation of the ED medication effect
Correct Answer: B
Rationale: ED drugs (PDE5 inhibitors) with nitrates cause severe vasodilation, leading to hypotension.
The patient is a 6-year-old child who is taking 125 mg of amoxicillin every 6 hours. Assuming that the half-life of Amoxicillin is 3 hours, how much Amoxicillin would be in the child's body at the time of the next administration of the drug?
- A. 62.5 mg
- B. 46.875 mg
- C. 31.25 mg
- D. 15.625 mg
Correct Answer: C
Rationale: The half-life of a drug is the time it takes for the amount of drug in the body to decrease to 1 half the peak level it previously achieved. Option A would occur at 3 hours after the original dose of amoxicillin. Option B would occur 4½ hours after the original dose. Option C would occur at 6 hours after the original dose. Option D would occur at 7½ hours after the original dose.
All are pro drugs except
- A. Sulindac
- B. Codeine
- C. Talampicillin
- D. Chlorpromazine
Correct Answer: D
Rationale: Chlorpromazine is active as is; others are prodrugs.
A nurse is preparing to administer acetaminophen 650 mg PO every 6 hr PRN for pain. The amount available is acetaminophen liquid 500 mg/5 mL. how many mL should the nurse administer per dose? (Round the answer to the nearest tenth. Use a leading zero if it applies. Do not use a trailing zero.)
- A. 6.5
- B. 5
- C. 4.8
- D. 6
Correct Answer: A
Rationale: Calculation: 650 mg ÷ (500 mg/5 mL) = 6.5 mL, matching the answer.