Questions Neurological System Related

Review Questions Neurological System related questions and content

A 63-year-old patient taking carbidopa/levodopa 25/100 mg four times a day for PD is experiencing end-of-dose wearing off. The best recommendation is to:

  • A. Add tolcapone.
  • B. Add entacapone.
  • C. Consider deep-brain stimulation (DBS).
  • D. Change carbidopa/levodopa to three times a day.
Correct Answer: B

Rationale: Entacapone, like tolcapone, is a COMT inhibitor that can help manage wearing-off symptoms by extending the duration of levodopa's effect.