Nokea
A child with severe asthma is being treated oral prednisone. Which of the following adverse effects is of particular concern?
- A. Hypoglycemia
- B. Hirsutism
- C. Growth suppression
- D. Cushing syndrome
Correct Answer: C
Rationale: Growth suppression is a significant concern in children on long-term prednisone due to its impact on bone growth and development.
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Potentially fatal granulocytopenia has been associated with treatment of hyperthyroidism with propylthiouracil. Patients should be taught to report:
- A. Tinnitus and decreased salivation
- B. Fever and sore throat
- C. Hypocalcemia and osteoporosis
- D. Laryngeal edema and difficulty swallowing
Correct Answer: B
Rationale: Fever and sore throat signal granulocytopenia with propylthiouracil; other symptoms are unrelated.
Frusemide is:
- A. A loop diuretic
- B. Osmotic diuretic
- C. Aldosterone antagonist
- D. A carbonic anhydrase inhibitor
Correct Answer: A
Rationale: Furosemide (Frusemide) is a loop diuretic that inhibits sodium and chloride reabsorption in the loop of Henle, leading to increased urine output.
Osteoporosis is a major adverse effect caused by the glucocorticoids. It is due to their ability to:
- A. Increase the excretion of calcium
- B. Inhibit absorption of calcium
- C. Stimulate the hypothalamic-pituitary-adrenal axis
- D. Decrease production of prostaglandins
Correct Answer: B
Rationale: Glucocorticoids inhibit calcium absorption in the gut, contributing to osteoporosis.
What is the correct statement concerning noncompetitive antagonism:
- A. The potency of the drug does not change
- B. the number of receptors able to bind the agonist is affected
- C. by increasing the conc. of the agonist, we cannot overcome the problem
- D. non of the above is wrong
Correct Answer: D
Rationale: All statements are correct: noncompetitive antagonism reduces efficacy (not potency), affects receptor availability, and cannot be overcome by increasing agonist concentration.
A nurse is caring for a client who has been taking Sertraline for the past 2 days. Which of the following assessment findings should alert the nurse to the possibility that the client is developing Serotonin syndrome?
- A. Bruising
- B. Fever
- C. Abdominal pain
- D. Rash
Correct Answer: B
Rationale: Fever is a key sign of serotonin syndrome, a potentially life-threatening condition from SSRI overdose.