ATI Pharmacology Proctored

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A healthcare provider is assessing a client who is taking levothyroxine. The healthcare provider should recognize that which of the following findings is a manifestation of levothyroxine overdose?

  • A. Insomnia
  • B. Constipation
  • C. Drowsiness
  • D. Hypoactive deep-tendon reflexes
Correct Answer: A

Rationale: The correct answer is A: Insomnia. Levothyroxine is a thyroid hormone replacement medication used to treat hypothyroidism. An overdose of levothyroxine can lead to hyperthyroidism symptoms, such as insomnia. This occurs due to an excess of thyroid hormone in the body, which can increase metabolism and disrupt sleep patterns. The other choices (B: Constipation, C: Drowsiness, D: Hypoactive deep-tendon reflexes) are not typical manifestations of a levothyroxine overdose. Constipation and drowsiness are more commonly associated with hypothyroidism, the condition being treated with levothyroxine. Hypoactive deep-tendon reflexes are not a typical symptom of either hypothyroidism or hyperthyroidism.

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Which of the following is not an effect of the drug isoflurane?

  • A. Elevated lipid levels
  • B. Nausea
  • C. Increased blood flow to the brain
  • D. Decreased respiratory function
Correct Answer: A

Rationale: The correct answer is A: Elevated lipid levels. Isoflurane does not cause elevated lipid levels. Isoflurane is a general anesthetic that primarily affects the central nervous system, leading to effects like decreased respiratory function and increased blood flow to the brain. Nausea can also be a side effect of isoflurane due to its impact on the gastrointestinal system. However, there is no direct link between isoflurane and elevated lipid levels. Thus, choice A is the correct answer.

A drug ending in the suffix (tidine) is considered a ______.

  • A. Antidepressant
  • B. Protease inhibitor
  • C. Beta antagonist
  • D. H antagonist
Correct Answer: D

Rationale: The correct answer is D: H antagonist. Drugs ending in the suffix (tidine) typically belong to the class of histamine H2-receptor antagonists. These drugs work by blocking the action of histamine on H2 receptors in the stomach, reducing the production of stomach acid. This is commonly used to treat conditions such as peptic ulcers and gastroesophageal reflux disease.

Explanation of other choices:
A: Antidepressant - Drugs ending in (pramine) or (ine) are more commonly associated with antidepressants.
B: Protease inhibitor - Drugs ending in (navir) are typically protease inhibitors used in antiviral therapy.
C: Beta antagonist - Drugs ending in (olol) are beta-blockers, which are used to treat conditions such as hypertension and heart disease, not related to (tidine) suffix.

Which of the following conditions are not treated with Barbiturates?

  • A. Seizures
  • B. Hypotension
  • C. Insomnia
  • D. Anxiety
Correct Answer: B

Rationale: Barbiturates are central nervous system depressants used to treat seizures, insomnia, and anxiety. However, they can worsen hypotension as they can cause vasodilation and decrease blood pressure. Choice B is correct because using barbiturates in hypotensive patients can lead to further lowering of blood pressure, potentially causing harm. Choices A, C, and D are incorrect as barbiturates are commonly used to treat seizures, insomnia, and anxiety, respectively, due to their sedative and anticonvulsant properties.

Which of the following is not directly related to drug toxicity of Nitroglycerin?

  • A. Headaches
  • B. Tachycardia
  • C. Dizziness
  • D. Projectile vomiting
Correct Answer: D

Rationale: The correct answer is D: Projectile vomiting. Nitroglycerin is not directly associated with causing projectile vomiting. Nitroglycerin commonly causes headaches due to vasodilation, tachycardia due to decreased preload, and dizziness due to hypotension. Projectile vomiting is not a typical side effect of Nitroglycerin toxicity.

A drug ending in the suffix (navir) is considered a ______.

  • A. Antidepressant
  • B. Protease inhibitor
  • C. Beta antagonist
  • D. H antagonist
Correct Answer: B

Rationale: The correct answer is B: Protease inhibitor. Drugs ending in the suffix (navir) are commonly used to inhibit protease enzymes in viruses, particularly in the treatment of HIV/AIDS. Protease inhibitors disrupt viral replication by preventing the cleavage of viral proteins, thus inhibiting the production of new infectious viral particles.
Choice A, Antidepressant, is incorrect as drugs used to treat depression usually end in (ine) or (pram).
Choice C, Beta antagonist, is incorrect as drugs affecting beta receptors typically end in (olol) or (lol).
Choice D, H antagonist, is incorrect as drugs targeting histamine receptors usually end in (ine) or (idine).

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