Nokea
A nurse is required to give an intramuscular (IM) injection to an 18-month-old toddler. The nurse would prepare which site for administration?
- A. Dorsogluteal site
- B. Deltoid muscle
- C. Vastus lateralis
- D. Ventrogluteal site
Correct Answer: C
Rationale: The vastus lateralis site is frequently used for infants and small children because it is more developed than the other intramuscular sites such as the dorsogluteal and deltoid muscle. Ventrogluteal sites may be used in children who have been ambulating for more than 2 years.
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What is the entry of drugs into the plasma?
- A. Absorption
- B. Distribution
- C. Elimination
- D. Metabolism
Correct Answer: A
Rationale: Absorption is the process by which a drug enters the plasma from its administration site, the first step in pharmacokinetics.
When prescribing Adderall (amphetamine and dextroamphetamine) to adults with ADHD the nurse practitioner will need to monitor:
- A. Blood pressure
- B. Blood glucose levels
- C. Urine ketone levels
- D. Liver function
Correct Answer: A
Rationale: Adderall increases blood pressure, requiring monitoring.
Which of the following concepts is considered when generic drugs are substituted for brand-name drugs?
- A. Bioavailability
- B. Critical concentration
- C. Distribution
- D. Half-life
Correct Answer: A
Rationale: Bioavailability is the portion of a dose of a drug that reaches the systemic circulation and is available to act on body cells. Binders used in a generic drug may not be the same as those used in the brand-name drug. Therefore, the way the body breaks down and absorbs the drug may differ, affecting its bioavailability.
Patients who have a poor metabolism phenotype will have:
- A. Slowed metabolism of a prodrug into an active drug, leading to accumulation of prodrug
- B. Accumulation of inactive metabolites of drugs
- C. A need for increased dosages of medications
- D. Increased elimination of an active drug
Correct Answer: A
Rationale: Poor metabolizers (e.g., CYP2D6) slowly convert prodrugs to active forms , causing prodrug buildup, not metabolite accumulation or faster elimination .
A nurse is providing teaching to a client who has a new prescription for Amitriptyline for treatment of depression. Which of the following should the nurse include in the teaching?
- A. Expect therapeutic effects in 24 to 48 hr.
- B. Discontinue the medication after a week of improved mood.
- C. Change positions slowly to minimize dizziness.
- D. Decrease injury from the first dose.
Correct Answer: C
Rationale: Slow position changes prevent dizziness, and chewing gum relieves dry mouth, common with tricyclics like amitriptyline.