Nokea
A patient taking an oral diuretic for about six (6) months presents with elevated fasting and post prandial blood glucose levels. You suspect the glycemic problems are diuretic induced. What is the most likely cause?
- A. Acetazolamide
- B. Amiloride
- C. Chlorothiazide
- D. Spironolactone
Correct Answer: C
Rationale: Thiazides like chlorothiazide impair glucose tolerance by reducing insulin sensitivity.
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AH are prodrugs except
- A. Enalapril
- B. Paracetamol
- C. Sulphamethoxazole
- D. Trimethoprim
Correct Answer: D
Rationale: Enalapril is a prodrug; paracetamol, sulphamethoxazole, and trimethoprim are active drugs.
Choose a drug that does not cause bradycardia:
- A. Clonidine
- B. Guanethidine
- C. Hydralazine causes reflex tactycardia
- D. Propranolol
Correct Answer: C
Rationale: Hydralazine causes reflex tachycardia, not bradycardia.
The drug used for the treatment of trachomoniasis is:
- A. Tetracycline
- B. Suramin
- C. Metronidazole
- D. Pyrimethamine
Correct Answer: C
Rationale: Metronidazole is the standard treatment for trichomoniasis, a protozoal infection caused by Trichomonas vaginalis, due to its specific antiprotozoal activity.
A nurse is caring for a client who is receiving daily doses of Oprelvekin. Which of the following laboratory values should the nurse monitor to determine effectiveness of this medication?
- A. Hemoglobin
- B. Absolute neutrophil count
- C. Platelet count
- D. Total white blood count
Correct Answer: C
Rationale: Oprelvekin increases platelet count , its primary therapeutic effect.
Tamoxifen is prescribed for the client with metastatic breast carcinoma. The nurse understands that the primary action of this medication is to:
- A. Increase DNA and RNA synthesis.
- B. Promote the biosynthesis of nucleic acids.
- C. Increase estrogen concentration and estrogen response.
- D. Compete with estradiol for binding to estrogen in tissues containing high concentrations of receptors.
Correct Answer: D
Rationale: Tamoxifen is an antineoplastic medication that competes with estradiol for binding to estrogen in tissues containing high concentrations of receptors. Tamoxifen is used to treat metastatic breast carcinoma in women and men. Tamoxifen is also effective in delaying the recurrence of cancer following mastectomy. Tamoxifen reduces DNA synthesis and estrogen response.