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A patient will be receiving penicillin G potassium, 12 million units daily in divided doses every 4 hours IVPB. Identify how many units the patient will receive for each dose each day.
Correct Answer: 2 million
Rationale: If a medication is given every 4 hours, then there will be 6 doses in each 24-hour day. (24 ?· 4 = 6). 12 million units ?· 6 doses = 2 million units/dose.
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A patient will be having oral surgery and has received an antibiotic to take for 1 week before the surgery. The nurse knows that this is an example of which type of therapy?
- A. Empiric
- B. Prophylactic
- C. Definitive
- D. Resistance
Correct Answer: B
Rationale: Prophylactic antibiotic therapy is used to prevent infection. Empiric therapy involves selecting the antibiotic that can best kill the microorganisms known to be the most common causes of an infection. Definitive therapy occurs once the culture and sensitivity results are known. Resistance is not a type of antibiotic therapy.
The nurse is monitoring for therapeutic results of antibiotic therapy in a patient with an infection. Which laboratory value would indicate therapeutic effectiveness of this therapy?
- A. Increased red blood cell count
- B. Increased hemoglobin level
- C. Decreased white blood cell count
- D. Decreased platelet count
Correct Answer: C
Rationale: Decreased white blood cell counts are an indication of reduction of infection and are a therapeutic effect of antibiotic therapy.
During drug therapy for pneumonia, a female patient develops a vaginal superinfection. The nurse explains that this infection is caused by which of these?
- A. Large doses of antibiotics that kill normal flora
- B. The infection spreading from the lungs to the new site of infection
- C. Resistance of the pneumonia-causing bacteria to the drugs
- D. An allergic reaction to the antibiotics
Correct Answer: A
Rationale: Normally occurring bacteria are killed during antibiotic therapy, allowing other flora to take over and resulting in superinfections.
The nurse is reviewing the medication history of a patient who will be taking a sulfonamide antibiotic. During sulfonamide therapy, a significant drug interaction may occur with which of these drugs or drug classes? (Select all that apply.)
- A. Opioids
- B. Oral contraceptives
- C. Sulfonylureas
- D. Antihistamines
- E. Phenytoin
- F. Warfarin
Correct Answer: B,C,E,F
Rationale: Sulfonamides may potentiate the hypoglycemic effects of sulfonylureas in diabetes treatment and the toxic effects of phenytoin. They also enhance the anticoagulant effects of warfarin, which can lead to hemorrhage. Sulfonamides may also reduce the efficacy of oral contraceptives. Opioids and antihistamines are not typically associated with significant interactions with sulfonamides.
During antibiotic therapy, the nurse will monitor closely for signs and symptoms of a hypersensitivity reaction. Which of these assessment findings may be an indication of a hypersensitivity reaction? (Select all that apply.)
- A. Wheezing
- B. Diarrhea
- C. Shortness of breath
- D. Swelling of the tongue
- E. Itching
- F. Black, hairy tongue
Correct Answer: A,C,D,E
Rationale: Hypersensitivity reactions may be manifested by wheezing; shortness of breath; swelling of the face, tongue, or hands; itching; or rash. Diarrhea and black, hairy tongue are not typically associated with hypersensitivity reactions but may be other side effects of antibiotic therapy.