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A patient with hypertension is prescribed an angiotensin-converting enzyme (ACE) inhibitor. Which adverse effect is most commonly associated with ACE inhibitors?

  • A. Hyperkalemia
  • B. Hypokalemia
  • C. Dry cough
  • D. Bradycardia
Correct Answer: C

Rationale: The most commonly associated adverse effect with ACE inhibitors is a dry cough. This cough is non-productive and can be quite bothersome for patients, often leading to non-compliance with the medication. The cough is thought to be due to the accumulation of bradykinin and substance P, which are vasodilatory and bronchoconstrictive peptides that are normally degraded by ACE. When ACE is inhibited, these peptides accumulate and can lead to irritation of the respiratory tract, resulting in the dry cough. It's important for healthcare providers to be aware of this common side effect and consider alternative medications if the cough becomes problematic for the patient.