Endocrine System Questions Related

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Adrenaline is NOT given orally because:

  • A. It is inactivated in the gut mucosa
  • B. Local vasoconstriction inhibits absorption
  • C. It is rapidly inactivated in circulation
  • D. All of the above
Correct Answer: D

Rationale: The correct answer is D: All of the above. Adrenaline is not given orally because: A) It is inactivated in the gut mucosa due to enzymatic breakdown, B) Local vasoconstriction inhibits absorption into the bloodstream, and C) It is rapidly inactivated in circulation by enzymes like catechol-O-methyltransferase and monoamine oxidase. Therefore, administering adrenaline orally would result in poor absorption and rapid degradation, making it ineffective.