Nokea
Adverse effects of atropine include the following EXCEPT:
- A. Excessive salivation
- B. Retention of urine
- C. Sinus tachycardia
- D. Constipation
Correct Answer: A
Rationale: The correct answer is A: Excessive salivation. Atropine is an anticholinergic medication that blocks the action of acetylcholine, leading to decreased secretions including saliva. Excessive salivation is not an adverse effect but rather a therapeutic effect of atropine. Choices B, C, and D are incorrect because retention of urine, sinus tachycardia, and constipation are known adverse effects of atropine due to its anticholinergic properties.
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A patient presents with increased growth of skeletal and soft tissue, hypertension, arthritis, menstrual disturbances, and diabetes mellitus. Upon administration of oral glucose, which of the following levels would increase?
- A. GH
- B. IGF
- C. GH and IGF
- D. ADH
Correct Answer: B
Rationale: The correct answer is B: IGF. Increased growth of skeletal and soft tissue, along with other symptoms, suggest acromegaly due to excess growth hormone (GH) secretion. GH stimulates the liver to produce insulin-like growth factor (IGF), which mediates many of GH's effects. In acromegaly, elevated IGF levels contribute to the clinical manifestations. Option A (GH) is incorrect because GH levels may be high but not necessarily in response to oral glucose. Option C (GH and IGF) is incorrect as GH alone does not directly increase in response to oral glucose. Option D (ADH) is unrelated to the scenario described.
Which mechanism is primarily responsible for maintaining hormone levels within a narrow range?
- A. negative feedback mechanisms
- B. positive feedback mechanisms
- C. hormone-receptor complexes
- D. hormone-gene complexes
Correct Answer: A
Rationale: The correct answer is A: negative feedback mechanisms. Negative feedback mechanisms help maintain hormone levels within a narrow range by inhibiting further hormone production once a certain level is reached. When hormone levels rise, negative feedback signals the body to decrease hormone production, preventing excessive levels. Positive feedback mechanisms, on the other hand, amplify hormone production. Hormone-receptor complexes and hormone-gene complexes are not directly responsible for maintaining hormone levels within a narrow range but rather play roles in hormone signaling and gene expression, respectively.
Mole for mole, which of the following has the greatest effect on plasma osmolality?
- A. Progesterone
- B. Cortisol
- C. Vasopressin
- D. Aldosterone
Correct Answer: C
Rationale: Plasma osmolality is primarily regulated by the concentration of solutes in the blood. Vasopressin, also known as antidiuretic hormone (ADH), plays a key role in regulating water reabsorption in the kidneys, thus affecting plasma osmolality. When plasma osmolality increases, vasopressin is released to increase water reabsorption, leading to a decrease in plasma osmolality. Progesterone, cortisol, and aldosterone do not directly influence water reabsorption and therefore do not have as significant an impact on plasma osmolality as vasopressin.
Thyroxine:
- A. is mostly bound to albumin in the plasma, since this has the largest capacity
- B. is 2-5 times more potent that triiodothyronine (T3)
- C. stimulates TSH release
- D. ∼33% is deiodinated in the liver to T3
Correct Answer: D
Rationale: The correct answer is D. Thyroxine is deiodinated in the liver to T3, so approximately 33% of thyroxine is converted to the more active form, triiodothyronine. This conversion is important for regulating metabolic processes in the body. Choices A and C are incorrect because thyroxine is primarily bound to thyroxine-binding globulin in the plasma, not albumin, and it does not stimulate TSH release. Choice B is incorrect because T3 is actually more potent than thyroxine, not the other way around.
Cushing syndrome:
- A. may be caused by steroid (prednisone) therapy.
- B. is caused by adrenal insufficiency.
- C. is characterized by hypoglycemia and low blood volume.
- D. is treated with growth hormone.
Correct Answer: A
Rationale: The correct answer is A because Cushing syndrome is typically caused by prolonged exposure to high levels of cortisol, which can result from steroid therapy like prednisone. This leads to symptoms such as weight gain, high blood pressure, and muscle weakness. Adrenal insufficiency (B) is actually the opposite condition. Cushing syndrome is characterized by hyperglycemia and increased blood volume, making choices C incorrect. Growth hormone is not a primary treatment for Cushing syndrome, making choice D incorrect.