Nokea
After admitting a patient to the unit, the nurse is organizing times to administer ordered medications. What important consideration will guide the nurse's timing of each medication?
- A. Comfort
- B. Ethnicity of patient
- C. Gender
- D. Age
Correct Answer: D
Rationale: Age affects metabolism and timing needs (e.g., elderly may need adjusted schedules).
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A primary health care provider instructs a nurse to administer a medication to a patient STAT. Which action by the nurse would be most appropriate?
- A. Insist on obtaining a written report before administering any drug.
- B. Administer the drug as ordered by the physician.
- C. Forgo obtaining the physician's order after the drug has been administered.
- D. Document the administration of the drug only after receiving the physician's order.
Correct Answer: B
Rationale: The nurse should administer the drug as instructed without a written order as it is an emergency. The nurse should, however, ensure that the physician's order is obtained after the drug has been administered. Waiting for a written order during an emergency may exacerbate the patient's condition. The nurse should complete the documentation immediately after the administration of the drug and not wait until the physician's order is received.
Ultra-rapid metabolizers of drugs may have:
- A. To have dosages of drugs adjusted downward to prevent drug accumulation
- B. Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure
- C. Increased elimination of active, nonmetabolized drug
- D. Slowed metabolism of a prodrug into an active drug, leading to an accumulation of prodrug
Correct Answer: B
Rationale: Ultra-rapid metabolizers (e.g., CYP2D6) quickly inactivate drugs , risking therapeutic failure, requiring higher doses, not lower or slowed metabolism .
A nurse is administering digoxin to a patient. To administer medications so that the drug is as effective as possible, the nurse needs to consider what?
- A. Pharmacotherapeutics
- B. Pharmacokinetics
- C. Pharmacoeconomics
- D. Pharmacogenomics
Correct Answer: B
Rationale: When administering a drug, the nurse needs to consider the phases of pharmacokinetics so that the drug regimen can be made as effective as possible. Pharmacogenomics is the area of study that includes mapping of the human genome. Pharmacotherapeutics is the branch of pharmacology that deals with the uses of drugs to treat, prevent, and diagnose disease. Pharmacoeconomics includes all costs involved in drug therapy.
Slow channel syndrome is due to
- A. Accumulation of Na+ ions in channels
- B. Accumulation of K+ ions in channels
- C. Accumulation of Mg++ ions in channels
- D. Accumulation of Ca++ ions in channels
Correct Answer: D
Rationale: Slow channel syndrome relates to calcium channel dysfunction.
Tamoxifen is prescribed for the client with metastatic breast carcinoma. The nurse understands that the primary action of this medication is to:
- A. Increase DNA and RNA synthesis.
- B. Promote the biosynthesis of nucleic acids.
- C. Increase estrogen concentration and estrogen response.
- D. Compete with estradiol for binding to estrogen in tissues containing high concentrations of receptors.
Correct Answer: D
Rationale: Tamoxifen is an antineoplastic medication that competes with estradiol for binding to estrogen in tissues containing high concentrations of receptors. Tamoxifen is used to treat metastatic breast carcinoma in women and men. Tamoxifen is also effective in delaying the recurrence of cancer following mastectomy. Tamoxifen reduces DNA synthesis and estrogen response.